ArticleOxidative medicine and cellular longevity2020
Huangbai Liniment Accelerated Wound Healing by Activating Nrf2 Signaling in Diabetes.
Article in Oxidative medicine and cellular longevity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 47 citations in OpenAlex.
- Fufang Huangbo Formula mitigates myeloproliferative neoplasms by activating p53/p21 signaling axis and inhibiting STAT3 and NF-κB signaling pathways.Pharmaceutical science advances · 2026Article
- Natural compounds for diabetes-related wounds or ulcers therapy: Evidence from preclinical and clinical studies.Journal of ginseng research · 2026Review
- Zn-Quer Nanozymes Reprogram the Malignant Phenotypic Transformation of Gastric Cancer Cells via Cascade Reactive Oxygen Species Coordination.ACS applied materials & interfaces · 2026Article
- Antimicrobial effects of compound Huangbai liquid onAmerican journal of translational research · 2026Article
- Chinese traditional medicine complex hemorrhoidal analgesic cream promotes wound healing in diabetic rats after anal fistula surgery via Keap1/Nrf2 signaling pathway.Biochemistry and biophysics reports · 2025Article
- Article
- Association between nutritional inflammation index and diabetic foot ulcers: a population-based study.Frontiers in nutrition · 2025Article
- Targeting oxidative damage in diabetic foot ulcers: integrative strategies involving antioxidant drugs and nanotechnologies.Burns & trauma · 2025Review
- Management of diabetic foot ulcers: polyherbal formulations and novel delivery systems for herbal active components.Frontiers in pharmacology · 2025Review
- Inflammation, diabetic foot and related treatments.Frontiers in endocrinology · 2025Review
- Integrated treatment utilizing both Chinese and Western medicine for refractory diabetic foot ulcers: a case report.Frontiers in endocrinology · 2025Article
- Multidimensional mechanisms of quercetin in diabetic kidney disease.Frontiers in cell and developmental biology · 2025Review
- A ROS-Responsive Lipid Nanoparticles Release Multifunctional Hydrogel Based on Microenvironment Regulation Promotes Infected Diabetic Wound Healing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Efficacy and pharmacoeconomic advantages of Fufang Huangbai Fluid hydropathic compress in diabetic foot infections: a comparative clinical study with antimicrobial calcium alginate wound dressing.Frontiers in pharmacology · 2024Article
- The Potential of MSC-Based Cell-Free Therapy in Wound Healing-A Thorough Literature Review.International journal of molecular sciences · 2023Review
- Research on the wound healing effect of Shengji Huayu Formula ethanol extract-derived fractions in streptozotocin-induced diabetic ulcer rats.BMC complementary medicine and therapies · 2023Article
- Targeting NRF2 to promote epithelial repair.Biochemical Society transactions · 2023Review
- Deciphering The Emerging Role of Programmed Cell Death in Diabetic Wound Healing.International journal of biological sciences · 2023Review
- [Research advances on the mechanism of refractory healing of diabetic foot ulcer].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2022Article
- Notoginsenoside R1 Facilitated Wound Healing in High-Fat Diet/Streptozotocin-Induced Diabetic Rats.Oxidative medicine and cellular longevity · 2022Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As a serious complication of diabetes, nonhealing skin ulcer leads to high mortality and disability in diabetic patients. However, limited therapy is available in managing diabetic wounds. In this study, RNA-seq technology was used to systematically investigate the effect of Huangbai (HB) liniment, a traditional Chinese medicine, on the streptozotocin- (STZ-) induced diabetic wound. HB liniment significantly accelerated the wound closure and enhanced the generation of extracellular matrix in diabetic rats, and oxidative stress was identified to play a vital role in HB-mediated wound healing. Importantly, HB liniment activated nuclear factor erythroid-derived 2-like 2 (Nrf2) and its downstream antioxidant genes (e.g., genes involved in glutathione system, thioredoxin system, and GAPDH generation as well as other antioxidant genes), which inhibited oxidative damage and apoptosis. By associating drug targets of HB liniment with Nrf2 and its downstream genes, 54 components in HB liniment were screened out, and the majority was from Cortex Phellodendri and Forsythia suspensa. Additionally, HB liniment enhanced TGF-
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