ArticleOncology letters2020
Clinical significance and diagnostic value of serum NSE, CEA, CA19-9, CA125 and CA242 levels in colorectal cancer.
Article in Oncology letters, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 1 of them a synthesis that pooled it.
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Who cites it
58 citing papers in PubMed, 1 synthesis or guideline pooled it, 97 citations in OpenAlex.
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- CT-based multi-station lymph-node radiomics for preoperative prediction of lymph node metastasis in colorectal cancer: a proof-of-concept comparison with primary-tumor radiomics.European radiology experimental · 2026Article
- The change in epidemiological characteristics and utilization of health services for the diagnosis and treatment of colorectal cancer: A hospital-based retrospective survey.Clinics (Sao Paulo, Brazil) · 2026Article
- Comparative Analytical Performance and Clinical Agreement of Chemiluminescence Microparticle Immunoassay and Electrochemiluminescence Immunoassay for CA19-9: A Diagnostic Accuracy Study.Diagnostics (Basel, Switzerland) · 2026Article
- Comparative performance of biopolymer-supported graphitic carbon nitride nanosheets for electrochemical carcinoembryonic antigen cancer biomarker detection in serum samples using smartphone device.Mikrochimica acta · 2026Article
- Composite proteomic and metabolomic plasma biomarkers for detection of colorectal, lung and ovarian cancers.Molecular cancer · 2026Article
- Proteome profiling reveals early diagnostic biomarker candidates for colorectal cancer.BMC cancer · 2026Article
- Aptamer-Based Strategies for Colorectal Cancer Detection: Emerging Technologies and Future Directions.Biosensors · 2025Review
- Predictive factors for the coexistence of colorectal lateral spreading tumors and colorectal polyps, and risk factors for malignancy.BMC gastroenterology · 2025Article
- Article
- Development and validation of a logistic regression model for the diagnosis of colorectal cancer.Scientific reports · 2025Article
- Screening colorectal cancer associated autoantigens through multi-omics analysis and diagnostic performance evaluation of corresponding autoantibodies.BMC cancer · 2025Article
- Enhancing the diagnostic accuracy of colorectal cancer through the integration of serum tumor markers and hematological indicators with machine learning algorithms.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025Article
- Biomarkers for colorectal cancer detection: An insight into colorectal cancer and FDA-approved biomarkers.BioImpacts : BI · 2025Review
- Clinical significance of risk factor analysis in pancreatic cancer by using supervised model of machine learning.Frontiers in medicine · 2025Article
- F-18 FDG PET/CT based Preoperative Machine Learning Prediction Models for Evaluating Regional Lymph Node Metastasis Status of Patients with Colon Cancer.Asian Pacific journal of cancer prevention : APJCP · 2025Article
- The relationship between serum CA50, CA242, and SAA levels and clinical pathological characteristics and prognosis in patients with pancreatic cancer.Open medicine (Warsaw, Poland) · 2025Article
- Biomarker detection based on nanoparticle-induced ultrasonic Rayleigh scattering.Microsystems & nanoengineering · 2024Review
- Construction of diagnostic models with machine-learning algorithms for colorectal cancer based on clinical laboratory parameters.Journal of gastrointestinal oncology · 2024Article
- A radiomics-boosted deep-learning for risk assessment of synchronous peritoneal metastasis in colorectal cancer.Insights into imaging · 2024Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study investigated the value of combinations of five specific tumor biomarkers for the diagnosis of colorectal cancer (CRC): Neuron-specific enolase (NSE), carcinoembryonic antigen (CEA), cancer antigen (CA)19-9, CA125 and CA242. Associations between these markers and clinicopathological characteristics (including the Tumor-Node-Metastasis stage) were also assessed. Serum levels of the 5 markers were compared between 358 patients with CRC and 298 healthy individuals (CRC and control group, respectively). The NSE concentration of the CRC group was significantly higher compared with the control. Furthermore, patients at clinical stage III+IV exhibited significantly higher NSE levels compared with those at stage I+II. The serum NSE level of N
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