Evidence map›Paper›PMID 32565715›Full record

ArticleSarcoma2020

Deep Functional and Molecular Characterization of a High-Risk Undifferentiated Pleomorphic Sarcoma.

Noah E Berlow, Catherine S Grasso, Michael J Quist, Mingshan Cheng, Regina Gandour-Edwards, Brian S Hernandez, Joel E Michalek, Christopher Ryan, Paul Spellman, Ranadip Pal and 3 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sarcoma, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Observational
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 8 institutions in 1 country.

Noah E BerlowChildren's Cancer Therapy Development Institute, Beaverton, OR 97005, USA.ORCID https://orcid.org/0000-0001-8666-3152
Catherine S GrassoDivision of Hematology-Oncology, University of California, Los Angeles, CA 90095, USA.
Michael J QuistDivision of Hematology-Oncology, University of California, Los Angeles, CA 90095, USA.
Mingshan ChengThe Jackson Laboratory, Bar Harbor, ME 04609, USA.
Regina Gandour-EdwardsDepartment of Pathology & Laboratory Medicine, UC Davis Health System, Sacramento, CA 95817, USA.
Brian S HernandezDepartment of Epidemiology and Biostatistics, University of Texas Health Science Center San Antonio, San Antonio, TX 78229, USA.
Joel E MichalekDepartment of Epidemiology and Biostatistics, University of Texas Health Science Center San Antonio, San Antonio, TX 78229, USA.
Christopher RyanSchool of Medicine, Oregon Health and Science University, Portland, OR 97239, USA.
Paul SpellmanSchool of Medicine, Oregon Health and Science University, Portland, OR 97239, USA.
Ranadip PalElectrical and Computer Engineering, Texas Tech University, Lubbock, TX 79409, USA.ORCID https://orcid.org/0000-0002-9311-5901
Lynn S MillionDepartment of Radiation Oncology, Stanford University, Stanford, CA 94305, USA.ORCID https://orcid.org/0000-0002-5931-4915
Mark RennekerPatient-Directed Consultations, San Francisco, CA 94116, USA.ORCID https://orcid.org/0000-0002-9311-5901
Charles KellerChildren's Cancer Therapy Development Institute, Beaverton, OR 97005, USA.ORCID https://orcid.org/0000-0003-2505-7487
Texas Tech University · USOregon Health & Science University · USThe University of Texas Health Science Center at San Antonio · USUniversity of California, Los Angeles · USJackson Laboratory · USStanford University · USUC Davis Health · USUniversity of California, San Francisco · US

Funding

Staff InvestigatorsP30CA093373 · NCI · UNIVERSITY OF CALIFORNIA DAVIS · PI Gina M Dayton · 2002 to 2026
$84.9M
6 · The paper itself

Abstract

Nonrhabdomyosarcoma soft-tissue sarcomas (STSs) are a class of 50+ cancers arising in muscle and soft tissues of children, adolescents, and adults. Rarity of each subtype often precludes subtype-specific preclinical research, leaving many STS patients with limited treatment options should frontline therapy be insufficient. When clinical options are exhausted, personalized therapy assignment approaches may help direct patient care. Here, we report the results of an adult female STS patient with relapsed undifferentiated pleomorphic sarcoma (UPS) who self-drove exploration of a wide array of personalized Clinical Laboratory Improvement Amendments (CLIAs) level and research-level diagnostics, including state of the art genomic, proteomic,

Identifiers

PMID32565715
PMCPMC7285280
OpenAlexW3031894658

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.