Evidence map›Paper›PMID 32565603›Full record

SynthesisIndian journal of pharmacology

Update on the target structures of SARS-CoV-2: A systematic review.

Manisha Prajapat, Phulen Sarma, Nishant Shekhar, Ajay Prakash, Pramod Avti, Anusuya Bhattacharyya, Hardeep Kaur, Subodh Kumar, Seema Bansal, Amit Raj Sharma and 1 more

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Indian journal of pharmacology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 5 syntheses or guidelines pooled it.

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  10. Yogic Neti-Kriya Using Povidone Iodine: Can it have a Preventive Role Against SARS-CoV-2 Infection Gateway?Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Manisha PrajapatDepartment of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Phulen SarmaDepartment of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Nishant ShekharDepartment of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Ajay PrakashDepartment of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Pramod AvtiDepartment of Biophysics, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Anusuya BhattacharyyaDepartments of Ophthalmology, Government Medical College and Hospital, Chandigarh, India.
Hardeep KaurDepartment of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Subodh KumarDepartment of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Seema BansalDepartment of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Amit Raj SharmaDepartment of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Bikash MedhiDepartment of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Knowledge of structural details is very much essential from the drug-design perspective. In the systematic review, we systematically reviewed the structural basis of different target proteins of SARS-corona virus (CoV2) from a viral life cycle and from drug design perspective. We searched four literature (PubMed, EMBASE, NATURE, and Willey online library) databases and one structural database (RCSB.org) with appropriate keywords till April 18, and finally, 26 articles were included in the systematic review. The published literature mainly centered upon the structural details of "spike protein," "main protease/M Pro/3CL pro," "RNA-dependent RNA polymerase," and "nonstructural protein 15 Endoribonuclease" of SARS-CoV-2. However, inhibitor bound structures were very less. We need better structures elucidating the interactions between different targets and their inhibitors which will help us in understanding the atomic level importance of different amino acid residues in the functionality of the target structures. To summarize, we need structures with fine resolution, co-crystallized structures with biologically validated inhibitors, and functional characterization of different target proteins. Some other routes of entry of SARS-CoV-2 are also mentioned (e.g., CD147); however, these findings are not structurally validated. This review may pave way for better understanding of SARS-CoV-2 life cycle from structural biology perspective.

Indexed as

Antiviral AgentsBetacoronavirusCoronavirus InfectionsCOVID-19COVID-19 Drug TreatmentDrug DesignHumansPandemicsPneumonia, ViralSARS-CoV-2Antiviral AgentsCOVID-19drug targetlife cycleSARS-corona virus-2target structures

Identifiers

PMID32565603
PMCPMC7282679

What OpenQuestion holds

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LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.