ArticleComputer methods in applied mechanics and engineering2020
Sensitivity analysis of a strongly-coupled human-based electromechanical cardiac model: Effect of mechanical parameters on physiologically relevant biomarkers.
Article in Computer methods in applied mechanics and engineering, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24 citing papers in PubMed, 76 citations in OpenAlex.
- Elucidating the cellular determinants of the end-systolic pressure-volume relationship of the heart via computational modelling.The Journal of physiology · 2026Article
- Cardiac remodelling in type 2 diabetes: Pathophysiological mechanisms and opportunities for multiscale computational modelling and simulation.The Journal of physiology · 2026Review
- Electromechanical modelling and simulation of human-induced pluripotent stem cell-derived cardiomyocytes predict drug-induced contractility effects.The Journal of physiology · 2026Article
- T-World Virtual Human Cardiomyocyte. II. Organ-Scale Simulations and Applications.Circulation research · 2026Article
- Systematic computational assessment of atrial function impairment due to fibrotic remodeling in electromechanical properties.PLoS computational biology · 2025Article
- Article
- Sex-specific human electromechanical multiscale in-silico models for virtual therapy evaluation.Journal of molecular and cellular cardiology plus · 2025Article
- Computational modelling for improved translation of cardiac inotropic and lusitropic drug effects from rats to humans.Journal of pharmacological and toxicological methods · 2025Article
- Fast and accurate prediction of drug induced proarrhythmic risk with sex specific cardiac emulators.NPJ digital medicine · 2024Article
- Article
- The Impact of Standard Ablation Strategies for Atrial Fibrillation on Cardiovascular Performance in a Four-Chamber Heart Model.Cardiovascular engineering and technology · 2023Article
- Mechanoelectric effects in healthy cardiac function and under Left Bundle Branch Block pathology.Computers in biology and medicine · 2023Article
- Design and execution of a verification, validation, and uncertainty quantification plan for a numerical model of left ventricular flow after LVAD implantation.PLoS computational biology · 2022Article
- Sensitivity analysis and inverse uncertainty quantification for the left ventricular passive mechanics.Biomechanics and modeling in mechanobiology · 2022Article
- An accurate, robust, and efficient finite element framework with applications to anisotropic, nearly and fully incompressible elasticity.Computer methods in applied mechanics and engineering · 2022Article
- Bayesian optimisation for efficient parameter inference in a cardiac mechanics model of the left ventricle.International journal for numerical methods in biomedical engineering · 2022Article
- An Integrated Workflow for Building Digital Twins of Cardiac Electromechanics-A Multi-Fidelity Approach for Personalising Active Mechanics.Mathematics (Basel, Switzerland) · 2022Article
- Enabling forward uncertainty quantification and sensitivity analysis in cardiac electrophysiology by reduced order modeling and machine learning.International journal for numerical methods in biomedical engineering · 2021Article
- Linking statistical shape models and simulated function in the healthy adult human heart.PLoS computational biology · 2021Article
- Human biventricular electromechanical simulations on the progression of electrocardiographic and mechanical abnormalities in post-myocardial infarction.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2021Article
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Authors and funding
13 authors at 2 institutions in 3 countries.
Funding
Abstract
The human heart beats as a result of multiscale nonlinear dynamics coupling subcellular to whole organ processes, achieving electrophysiologically-driven mechanical contraction. Computational cardiac modelling and simulation have achieved a great degree of maturity, both in terms of mathematical models of underlying biophysical processes and the development of simulation software. In this study, we present the detailed description of a human-based physiologically-based, and fully-coupled ventricular electromechanical modelling and simulation framework, and a sensitivity analysis focused on its mechanical properties. The biophysical detail of the model, from ionic to whole-organ, is crucial to enable future simulations of disease and drug action. Key novelties include the coupling of state-of-the-art human-based electrophysiology membrane kinetics, excitation-contraction and active contraction models, and the incorporation of a pre-stress model to allow for pre-stressing and pre-loading the ventricles in a dynamical regime. Through high performance computing simulations, we demonstrate that 50% to 200%
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.