Evidence map›Paper›PMID 32565465›Full record

ArticleBMJ open2020

Study protocol for the safety and efficacy of probiotic therapy on days alive and out of hospital in adult ICU patients: the multicentre, randomised, placebo-controlled Restoration Of gut microflora in Critical Illness Trial (ROCIT).

Edward Litton, Matthew Anstey, David Broadhurst, Andy R Chapman, Andrew Currie, Janet Ferrier, Joel Gummer, Alisa Higgins, Jolene Lim, Laurens Manning and 14 more

Open access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Probiotics in Critically Ill Patients: An Umbrella Review.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 9 institutions in 2 countries.

Edward LittonIntensive Care Unit, Fiona Stanley Hospital, Murdoch, Western Australia, Australia ed.litton@health.wa.gov.au.ORCID 0000-0002-5125-6829
Matthew AnsteyIntensive Care Unit, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia.
David BroadhurstSchool of Science, Edith Cowan University, Joondalup, Western Australia, Australia.
Andy R ChapmanIntensive Care Unit, Royal Perth Hospital, Perth, Western Australia, Australia.
Andrew CurrieMurdoch University, Murdoch, Western Australia, Australia.
Janet FerrierIntensive Care Unit, St John of God Hospital, Subiaco, Western Australia, Australia.
Joel GummerMurdoch University, Murdoch, Western Australia, Australia.
Alisa HigginsAustralian and New Zealand Intensive Care Research Centre, Monash University, Clayton, Victoria, Australia.
Jolene LimIntensive Care Unit, Fiona Stanley Hospital, Murdoch, Western Australia, Australia.
Laurens ManningUniversity of Western Australia, Perth, Western Australia, Australia.
Erina MyersIntensive Care Unit, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia.
Katrina OrrPharmacy, Fiona Stanley Hospital, Murdoch, Western Australia, Australia.
Anne-Marie PalermoIntensive Care Unit, Fiona Stanley Hospital, Murdoch, Western Australia, Australia.
Andrew PapariniMurdoch University, Murdoch, Western Australia, Australia.
Susan PellicanoIntensive Care Unit, Fiona Stanley Hospital, Murdoch, Western Australia, Australia.
Edward RabyDepartment of Infectious Diseases, Fiona Stanley Hospital, Murdoch, Western Australia, Australia.
Anu RammohanDepartment of Economics, University of Western Australia, Crawley, Western Australia, Australia.
Adrian RegliIntensive Care Unit, Fiona Stanley Hospital, Murdoch, Western Australia, Australia.
Bernhard RichterIntensive Care Unit, Fiona Stanley Hospital, Murdoch, Western Australia, Australia.
Sam SalmanUniversity of Western Australia, Perth, Western Australia, Australia.
Tobias StrunkNeonatal Directorate, King Edward Memorial Hospital for Women Perth, Subiaco, Western Australia, Australia.
Sharon WatersonIntensive Care Unit, Royal Perth Hospital, Perth, Western Australia, Australia.
Brad WibrowIntensive Care Unit, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia.
Fiona M WoodUniversity of Western Australia, Perth, Western Australia, Australia.
Fiona Stanley Hospital · AUThe University of Western Australia · AUMurdoch University · AUSir Charles Gairdner Hospital · AURoyal Perth Hospital · AUSt John of God Subiaco Hospital · AUAustralian and New Zealand Intensive Care Society · AUEdith Cowan University · AUKing Edward Memorial Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe effect of early and sustained administration of daily probiotic therapy on patients admitted to the intensive care unit (ICU) remains uncertain. METHODS AND ANALYSIS: The Restoration Of gut microflora in Critical Illness Trial (ROCIT) study is a multicentre, randomised, placebo-controlled, parallel-group, two-sided superiority trial that will enrol 220 patients in five ICUs. Adult patients who are within 48 hours of admission to an ICU and are expected to require intensive care beyond the next calendar day will be randomised in a 1:1 ratio to receive early and sustained ETHICS AND DISSEMINATION: ROCIT has been approved by the South Metropolitan Health Service Human Research Ethics Committee (ref: RGS00000004) and the St John of God Health Care Human Research Ethics Committee (ref: 1183). The trial results will be submitted for publication in a peer-reviewed journal. TRIAL REGISTRATION NUMBER: Australian and New Zealand Clinical Trials Registry (ANZCTR12617000783325); Pre-results.

Indexed as

Critical IllnessEquivalence Trials as TopicGastrointestinal MicrobiomeAustraliaCritical CareHumansIntensive Care UnitsMulticenter Studies as TopicNew ZealandProbioticsResearch Designadult intensive & critical carediagnostic microbiology

Identifiers

PMID32565465
PMCPMC7311035
OpenAlexW3036195002

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.