Observational studyThe journal of allergy and clinical immunology. In practice2020
Prompt Predicting of Early Clinical Deterioration of Moderate-to-Severe COVID-19 Patients: Usefulness of a Combined Score Using IL-6 in a Preliminary Study.
Observational study in The journal of allergy and clinical immunology. In practice, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.
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Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it, 80 citations in OpenAlex.
- Charlson comorbidity index and a composite of poor outcomes in COVID-19 patients: A systematic review and meta-analysis.Diabetes & metabolic syndromePooled it
- Risk factors and predicting nomogram for the clinical deterioration of non-severe community-acquired pneumonia.BMC pulmonary medicine · 2024Trial
- Interleukin-6 Is a Biomarker for the Development of Fatal Severe Acute Respiratory Syndrome Coronavirus 2 Pneumonia.Frontiers in immunology · 2021Trial
- Lisinopril increases lung ACE2 levels and SARS-CoV-2 viral load and decreases inflammation but not disease severity in experimental COVID-19.Frontiers in pharmacology · 2024Article
- Predicting the outcome of death by CALL Score in COVID-19 patients.Revista da Associacao Medica Brasileira (1992) · 2024Article
- Predicting Deterioration from Wearable Sensor Data in People with Mild COVID-19.Sensors (Basel, Switzerland) · 2023Article
- The Effects of a Pulmonary Rehabilitation Program in Severe and Critical COVID-19 Disease: A Prospective Observational Study.Journal of clinical practice and research · 2023Article
- Expression of IFN-Gamma is significantly reduced during severity of covid-19 infection in hospitalized patients.PloS one · 2023Article
- How the Immune System Responds to Allergy Immunotherapy.Biomedicines · 2022Review
- The relationship between C-reactive protein and levels of various cytokines in patients with COVID-19: A systematic review and correlation analysis.Health science reports · 2022Article
- The PaCO2/FiO2 ratio as outcome predictor in SARS-COV-2 related pneumonia: a retrospective study.Acta bio-medica : Atenei Parmensis · 2022Article
- Predicting progression to severe COVID-19 using the PAINT score.BMC infectious diseases · 2022Article
- Incubation period, clinical and lung CT features for early prediction of COVID-19 deterioration: development and internal verification of a risk model.BMC pulmonary medicine · 2022Article
- Comparison of laboratory parameters in mildJournal of thoracic disease · 2022Article
- What we know and still ignore on COVID-19 immune pathogenesis and a proposal based on the experience of allergic disorders.Allergy · 2022Review
- Elevated Levels of Pleiotropic Interleukin-6 (IL-6) and Interleukin-10 (IL-10) are Critically Involved With the Severity and Mortality of COVID-19: An Updated Longitudinal Meta-Analysis and Systematic Review on 147 Studies.Biomarker insights · 2022Article
- IL-6 and other biomarkers as predictors of severity in COVID-19.Annals of medicine · 2021Article
- Research on SARS-COV-2 pandemic: a narrative review focused on the Italian contribution.Journal of anesthesia, analgesia and critical care · 2021Review
- High-value laboratory testing for hospitalized COVID-19 patients: a review.Future virology · 2021Review
- Virus Induced Lymphocytes (VIL) as a novel viral antigen-specific T cell therapy for COVID-19 and potential future pandemics.Scientific reports · 2021Article
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Authors and funding
28 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe early identification of patients at risk of clinical deterioration is of interest considering the timeline of COVID-19 after the onset of symptoms.
objectiveThe aim of our study was to evaluate the usefulness of testing serum IL-6 and other serological and clinical biomarkers, to predict a short-term negative clinical course of patients with noncritical COVID-19.
methodsA total of 208 patients with noncritical COVID-19 pneumonia at admission were consecutively enrolled. Clinical and laboratory findings obtained on admission were analyzed by using survival analysis and stepwise logistic regression for variable selection. Three-day worsening as outcome in a logistic model to generate a prognostic score was used.
resultsClinical worsening occurred in 63 patients (16 = died; 39 = transferred to intensive care unit; 8 worsening of respiratory failure). Forty-five of them worsened within 3 days after admission. The risk of clinical worsening was progressively enhanced along with increasing quartiles of IL-6 levels. Multivariate analysis showed that IL-6 (P = .005), C-reactive protein (CRP) (P = .003), and SaO
conclusionsCombining IL-6, CRP, and SaO
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