ReviewTrends in cardiovascular medicine2021
Premature atherosclerotic peripheral artery disease: An underrecognized and undertreated disorder with a rising global prevalence.
Review in Trends in cardiovascular medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 3 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Diagnosis models to predict peripheral arterial disease: a systematic review and meta analysis.Scientific reports · 2025Pooled it
- Pooled it
- Peripheral artery disease: an underdiagnosed condition in familial hypercholesterolemia? A systematic review.Endocrine · 2024Pooled it
- Assessing the Correlation Between Inter-Leg Ankle-Brachial Index Asymmetry and Peripheral Artery Disease Outcomes.Journal of cardiovascular development and disease · 2026Article
- Trefoil Factor 3 as a Biomarker for Peripheral Artery Disease.Biomolecules · 2026Article
- The Association Between Abnormal Electrocardiogram Findings and the Ankle Brachial Index.Medicina (Kaunas, Lithuania) · 2026Article
- Association Between Intra-Leg Ankle-Brachial Index Asymmetry and Major Adverse Limb Events in Patients with Peripheral Artery Disease.Journal of clinical medicine · 2026Article
- Comparison of Fatty Acid Binding Protein 3 and Ankle Brachial Index for Predicting Peripheral Artery Disease Outcomes.Biomolecules · 2026Article
- Prevalence and types of lower limb conditions in Nepal.Journal of global health · 2026Article
- Premature "asymptomatic" peripheral artery disease and correlates among HIV-positive adults in Ghana: findings from the SCRIPT study.BMC cardiovascular disorders · 2026Article
- Interaction and biological pathway analysis of proteomic products in patients with premature coronary artery disease.Clinical proteomics · 2025Article
- Global burden of peripheral arterial disease and its risk factors, 1990-2021.BMC cardiovascular disorders · 2025Article
- Investigation of Growth Differentiation Factor 15 as a Prognostic Biomarker for Major Adverse Limb Events in Peripheral Artery Disease.Journal of clinical medicine · 2025Article
- Association between neutrophil percentage-to-albumin ratio and prevalence peripheral artery disease in U.S. adults: a cross-sectional study from the NHANES.BMC cardiovascular disorders · 2025Article
- Association Between Magnesium Depletion Score and Peripheral Artery Disease in Middle-Aged and Older Population.Journal of cardiovascular translational research · 2025Article
- Trans-ethnic Mendelian randomization analysis of membranous nephropathy and peripheral artery disease with mediating effects of thrombomodulin.Scientific reports · 2025Article
- Prediction of Major Adverse Limb Events in Females with Peripheral Artery Disease using Blood-Based Biomarkers and Clinical Features.Journal of cardiovascular translational research · 2025Article
- Exploring the hemoglobin-to-red blood cell distribution width ratio (HRR) to peripheral arterial disease nexus: a comprehensive analysis of NHANES data from 1999 to 2004.Frontiers in pharmacology · 2025Article
- Investigating the Prognostic Potential of Plasma ST2 in Patients with Peripheral Artery Disease: Identification and Evaluation.Proteomes · 2024Article
- Inflammatory Protein Panel: Exploring Diagnostic Insights for Peripheral Artery Disease Diagnosis in a Cross-Sectional Study.Diagnostics (Basel, Switzerland) · 2024Article
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13 authors at 2 institutions in 1 country.
Funding
Abstract
Premature atherosclerotic peripheral artery disease (PAD) of the lower extremities is characterized by disease diagnosis before the age of 50 years. The global prevalence of premature PAD has increased, and the disease is often underdiagnosed given heterogenous patient symptoms. Traditional cardiovascular risk factors like smoking, diabetes, hypertension, and hyperlipidemia as well as non-traditional risk factors like elevated lipoprotein(a), family history of PAD, hypercoagulability, and systemic inflammation are associated with premature PAD. Patients with premature PAD tend to have an aggressive vascular disease process, a high burden of cardiovascular risk factors, and other concomitant atherosclerotic vascular diseases like coronary artery disease. Prevention of cardiovascular events, improvement of symptoms and functional status, and prevention of adverse limb events are the main goals of patient management. In this review, we discuss the epidemiology, risk factors, clinical evaluation, and management of patients with premature PAD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.