Evidence map›Paper›PMID 32564438›Full record

Trial reportJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2020

Regular Supplementation With Resveratrol Improves Bone Mineral Density in Postmenopausal Women: A Randomized, Placebo-Controlled Trial.

Rachel Hx Wong, Jay Jay Thaung Zaw, Cory J Xian, Peter Rc Howe

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
86citing papers in PubMed, 9 pooled it
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

86 citing papers in PubMed, 9 syntheses or guidelines pooled it, 135 citations in OpenAlex.

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  10. Pro-Osteogenic Effect of the Nutraceutical BlastiMin ComplexInternational journal of molecular sciences · 2024
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26 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Rachel Hx WongSchool of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, Australia.ORCID 0000-0002-6550-5646
Jay Jay Thaung ZawSchool of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, Australia.
Cory J XianUniSA Clinical & Health Sciences and Cancer Research Institute, University of South Australia, Adelaide, Australia.ORCID 0000-0002-8467-2845
Peter Rc HoweSchool of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, Australia.ORCID 0000-0001-6546-7742
University of South Australia · AUUniversity of Newcastle Australia · AUUniversity of Southern Queensland · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Resveratrol, a naturally occurring polyphenol in red grapes and berries, can act as a phytoestrogen. It has been shown to improve both systemic and cerebral circulatory functions, possibly through activation of endothelial estrogen receptors. in vitro and in vivo studies in rodent models also indicate a bone-protective role for resveratrol, particularly in ovariectomized rat models that mimic postmenopausal osteoporosis caused by estrogen deficiency. Hypothesizing a circulatory benefit of resveratrol in bone tissue, we investigated whether resveratrol supplementation could improve bone health in postmenopausal women. The Resveratrol for Healthy Aging in Women (RESHAW) trial was a 24-month randomized, double-blind, placebo-controlled, two-period crossover intervention conducted to evaluate the effects of resveratrol (75 mg twice daily) on cognition, cerebrovascular function, bone health, cardiometabolic markers, and well-being in postmenopausal women. After 12 months of supplementation with resveratrol versus placebo, there were positive effects on bone density in the lumbar spine (+0.016 ± 0.003 g/cm

Indexed as

Bone DensityOsteoporosis, PostmenopausalAnimalsDietary SupplementsDouble-Blind MethodFemaleFemur NeckHumansPostmenopauseRatsResveratrolResveratrolAGINGCLINICAL TRIALSDXAMENOPAUSENUTRITION

Identifiers

PMID32564438
PMCPMC7689937
OpenAlexW3036296615

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.