SynthesisHeart failure reviews2022
Association of loop diuretics use and dose with outcomes in outpatients with heart failure: a systematic review and meta-analysis of observational studies involving 96,959 patients.
Synthesis in Heart failure reviews, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
- Diuretics in Cardiovascular Disease: For How Long and at What Dose?Journal of cardiovascular development and disease · 2026Review
- Impact of Late ARNI Initiation on Quality of Life and Functional Capacity in CRT-Treated HFrEF Patients: A Single-Centre Cohort Study.Journal of clinical medicine · 2026Article
- Evaluation of the Frequency of Hypokalemia in Patients on Diuretic Therapy for Heart Failure.Cureus · 2025Article
- Phenotype and outcomes according to loop diuretic use in pulmonary arterial hypertension.ESC heart failure · 2024Observational
- The Importance of Optimal Hydration in Patients with Heart Failure-Not Always Too Much Fluid.Biomedicines · 2023Review
- Utility of fractional excretion of urea nitrogen in heart failure patients with chronic kidney disease.ESC heart failure · 2023Article
- SGLT2 inhibitor and loop diuretic induce different vasopressin and fluid homeostatic responses in nondiabetic rats.American journal of physiology. Renal physiology · 2022Article
- Performance assessment across different care settings of a heart failure hospitalisation risk-score for type 2 diabetes using administrative claims.Scientific reports · 2022Article
- Prognostic differences in long-standing vs. recent-onset dilated cardiomyopathy.ESC heart failure · 2022Article
- Cancer Incidence and Mortality According to Pre-Existing Heart Failure in a Community-Based Cohort.JACC. CardioOncology · 2022Article
- Telehealth Management and Risk Stratification of Older Patients With Chronic Heart Failure During COVID-19 Pandemic: Prognostic Evaluation of the TeleHFCovid19-Score.Journal of the American Medical Directors Association · 2022Observational
- Dose of furosemide before admission predicts diuretic efficiency and long-term prognosis in acute heart failure.ESC heart failure · 2022Observational
- A heart failure program in low-income patients in Argentina (COMM-HF).Archivos peruanos de cardiologia y cirugia cardiovascularArticle
- Decongestion in chronic heart failure.JRSM cardiovascular diseaseReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is ongoing controversy regarding the association between loop diuretics (LD), especially in high doses, and adverse clinical outcomes in outpatients with heart failure (HF). We performed a systematic review of the evidence for LD in outpatients with HF. We searched MEDLINE, EMBASE, and Cochrane Clinical Trial Collection to identify controlled studies, evaluating the association between LD and morbidity and mortality in patients with HF. The primary endpoint was all-cause mortality and secondary endpoint HF hospitalizations. Quantitative analysis was performed by generating forest plots and pooling adjusted risk estimates across studies using random effects models. Between-study heterogeneity was assessed through Q and I
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.