ArticleQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2020
The association between sociodemographic factors, frailty, and health-related quality of life in older inpatients: a cross-sectional study.
Article in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systematic review and meta-analysis of the prevalence of frailty and pre-frailty amongst older hospital inpatients in low- and middle-income countries.Age and ageing · 2025Pooled it
- The association between frailty and quality of life in elderly population in Southern Iran: Findings from the Bushehr Elderly Health Program.BMC geriatrics · 2026Article
- The Relationship Between Health-Related Quality of Life and Frailty in Older Patients Participating in Early Phase II Cardiac Rehabilitation.Circulation reports · 2025Article
- Factors Associated with Medication Adherence among Community-Dwelling Older People with Frailty and Pre-Frailty in China.International journal of environmental research and public health · 2022Article
- Research on the frailty status and adverse outcomes of elderly patients with multimorbidity.BMC geriatrics · 2022Article
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Authors and funding
3 authors.
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Abstract
purposeThis cross-sectional study aims to explore the association between frailty and domains of quality of life (QOL) among hospitalized patients in older age under consideration of the sociodemographic characteristics.
methodsOlder inpatients in a comprehensive tertiary hospital in China were involved. Data including sociodemographic, clinical diagnosis, frailty status, and QOL were collected through questionnaires and physical assessments. Frailty was measured using the frailty phenotype defined by Fried. QOL was determined by completion of version 2 of the 12-item Short Form Survey (SF-12v2). Multivariable linear regression and structural equation modeling were applied to estimate associations between frailty and QOL.
results260 older inpatients were enrolled and classified as frail (31.92%), pre-frail (39.62%), and robust (28.46%). Patients with frailty were older and were more likely to have severe comorbidity, higher nutritional risk score and lower body mass index, activities of daily living score (P < 0.05). As the extent of frailty increased, the patients in old age experienced poor QOL in most of dimensions. Five multiple linear regression models indicated that the estimated differences in the physical component summary of QOL were lower for the frail and pre-frail groups versus the robust group. After adjusting all covariates, the coefficients were - 7.72 (- 11.04, - 4.41) and - 16.48 (- 20.37, - 12.58) for pre-frail and frail, respectively. Structural equation modeling results showed that sociodemographic characteristics directly affected QOL, while others played an indirect role in reducing their QOL by causing frailty.
conclusionsFrailty is prevalent in hospitalized patients having older age. Patients with frailty would experience poor QOL, especially in the dimension of physical health. To promote healthy aging, further studies into how frailty influences the QOL is warranted.
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