Evidence map›Paper›PMID 32564257›Full record

ArticleMikrochimica acta2020

Gold nanoparticle-modified black phosphorus nanosheets with improved stability for detection of circulating tumor cells.

Shuping Liu, Junjun Luo, Xingxing Jiang, Xiaoqing Li, Minghui Yang

Abstract read
PubMed Publisher
In one paragraph

Article in Mikrochimica acta, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Circulating tumor cells: biology and clinical significance.Signal transduction and targeted therapy · 2021
    Review
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Shuping LiuHunan Provincial Key Laboratory of Micro & Nano Materials Interface Science, College of Chemistry and Chemical Engineering, Central South University, Changsha, 410083, Hunan, People's Republic of China.
Junjun LuoHunan Provincial Key Laboratory of Micro & Nano Materials Interface Science, College of Chemistry and Chemical Engineering, Central South University, Changsha, 410083, Hunan, People's Republic of China.
Xingxing JiangHunan Provincial Key Laboratory of Micro & Nano Materials Interface Science, College of Chemistry and Chemical Engineering, Central South University, Changsha, 410083, Hunan, People's Republic of China.
Xiaoqing LiHunan Provincial Key Laboratory of Micro & Nano Materials Interface Science, College of Chemistry and Chemical Engineering, Central South University, Changsha, 410083, Hunan, People's Republic of China.
Minghui YangHunan Provincial Key Laboratory of Micro & Nano Materials Interface Science, College of Chemistry and Chemical Engineering, Central South University, Changsha, 410083, Hunan, People's Republic of China. yangminghui@csu.edu.cn.ORCID 0000-0002-7612-8137

Funding

Hunan Provincial Science and Technology Plan Project 2019TP1001Innovation-Driven Project of Central South University 2020CX002
6 · The paper itself

Abstract

Gold nanoparticle (AuNP)-anchored BP nanosheets were synthesized through in situ growth of AuNPs onto BP. Due to the strong chelating ability of P or phosphorus oxides with AuNPs, the stability of BP is improved. As proof-of-concept demonstration of the functionalized BP, electrochemical detection of circulating tumor cells (CTCs) based on BP@AuNPs@aptamer as a probe combined with immunomagnetic separation is reported. The aptamer can specifically bind with CTCs, while the phosphorus oxides including phosphite ion and phosphate ion (PxOy species) on BP and aptamer can react with molybdate to generate an electrochemical current, leading to dual signal amplification. The biosensor is applied to MCF-7 cell detection and displays good analytical performance with a detection limit of 2 cell mL

Indexed as

Antibodies, ImmobilizedAptamers, NucleotideBase SequenceBiosensing TechniquesCell Line, TumorElectrochemical TechniquesEpithelial Cell Adhesion MoleculeGoldHumansImmobilized Nucleic AcidsImmunomagnetic SeparationLimit of DetectionMetal NanoparticlesMolybdenumMucin-1Neoplastic Cells, CirculatingAntibodies, ImmobilizedAptamers, NucleotideEPCAM protein, humanEpithelial Cell Adhesion MoleculeGoldImmobilized Nucleic AcidsMolybdenumMUC1 protein, humanMucin-1Phosphorussodium molybdate(VI)BP nanosheetsCirculating tumor cellsElectrochemical detectionGold nanoparticlesImmunomagnetic separation

Identifiers

PMID32564257

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.