Evidence map›Paper›PMID 32564196›Full record

Trial reportAnnals of hematology2020

Sequential allogeneic hematopoietic stem cell transplantation for active refractory/relapsed myeloid malignancies: results of a reduced-intensity conditioning preceded by clofarabine and cytosine arabinoside, a retrospective study on behalf of the SFGM-TC.

Amandine Le Bourgeois, Myriam Labopin, Ambroise Marçais, Regis Peffault de Latour, Didier Blaise, Sylvain Chantepie, Stéphanie N'Guyen, Natacha Maillard, Edouard Forcade, Ibrahim Yakoub-Agha and 12 more

Abstract readClinical TrialMulticenter Study
PubMed Publisher
In one paragraph

Trial report in Annals of hematology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.6field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

  1. Trial
  2. Article
  3. New age HCT conditioning regimens: what works and why?Hematology. American Society of Hematology. Education Program · 2025
    Review
  4. Review
  5. Review
  6. Is There (Still) a Place for Sequential Conditioning?Current oncology (Toronto, Ont.) · 2025
    Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 17 institutions in 2 countries.

Amandine Le BourgeoisDepartment of Hematology, CHU Hôtel Dieu, Place A. Ricordeau, 44093, Nantes Cedex, France. amandine.lebourgeois@chu-nantes.fr.ORCID http://orcid.org/0000-0002-0370-7867
Myriam LabopinDepartment of Hematology, Hôpital Saint Antoine, Sorbonne University and INSERM UMRs 938, Paris, France.
Ambroise MarçaisDepartment of Hematology, Hôpital Necker-Enfants Malades, Paris, France.
Regis Peffault de LatourDepartment of Hematology, Hôpital Saint Louis & Université Paris 7, Denis Diderot, Paris, France.
Didier BlaiseDepartment of Hematology, Centre de Recherche en Cancérologie de Marseille, Institut Paoli Calmettes, Marseille, France.
Sylvain ChantepieDepartment of Hematology, CHU de Caen, Caen, France.
Stéphanie N'GuyenDepartment of Hematology, Hôpital Salpétrière, Paris, France.
Natacha MaillardDepartment of Hematology, Hôpital La Miletrie, Poitiers, France.
Edouard ForcadeDepartment of Hematology, CHU de Bordeaux, Bordeaux, France.
Ibrahim Yakoub-AghaLIRIC INSERM U995, Université Lille 2, CHU de Lille, Lille, France.
Anne HuynhDepartment of Hematology, CHU de Toulouse, Toulouse, France.
Tony MarchandDepartment of Hematology, CHU de Rennes, Rennes, France.
Karin BilgerDepartment of Hematology, CHU de Strasbourg, Strasbourg, France.
Patrice CeballosDepartment of Hematology, CHU de Montpellier, Montpellier, France.
Amandine CharbonnierDepartment of Hematology, CHU d'Amiens Sud, Amiens, France.
Pascal TurlureDepartment of Hematology, CHU de Limoges, Limoges, France.
Marie-Thérese RubioDepartment of Hematology, CHU de Nancy, Nancy, France.
Marie Christine BénéDepartment of Hematology, CHU Hôtel Dieu, Place A. Ricordeau, 44093, Nantes Cedex, France.
Thierry GuillaumeDepartment of Hematology, CHU Hôtel Dieu, Place A. Ricordeau, 44093, Nantes Cedex, France.
Mohamad MohtyDepartment of Hematology, Hôpital Saint Antoine, Sorbonne University and INSERM UMRs 938, Paris, France.
Patrice ChevallierDepartment of Hematology, CHU Hôtel Dieu, Place A. Ricordeau, 44093, Nantes Cedex, France. patrice.chevallier@chu-nantes.fr.
Société Francophone de Greffe de Moelle et de Thérapie Cellulaire
Hotel Dieu Hospital · CAInserm · FRCentre Hospitalier Régional et Universitaire de Nancy · FRCentre Hospitalier Universitaire Amiens-Picardie · FRCentre Hospitalier Universitaire de Bordeaux · FRCentre Hospitalier Universitaire de Caen Normandie · FRCentre Hospitalier Universitaire de Limoges · FRCentre Hospitalier Universitaire de Montpellier · FRCentre Hospitalier Universitaire de Nantes · FRCentre Hospitalier Universitaire de Poitiers · FRCentre Hospitalier Universitaire de Rennes · FRCentre Hospitalier Universitaire de Toulouse · FRDélégation Paris 7 · FRHôpital Necker-Enfants Malades · FRInstitut Pprime · FRLaboratoire d’HYdrologie et de GEochimie · FRSorbonne Université · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Allogeneic stem cell transplantation (allo-SCT) represents the most beneficial treatment for patients with active relapsed/refractory (R/R) hematologic malignancies. Recently, sequential regimens combining debulking chemotherapy followed by reduced-intensity conditioning (RIC) have shown encouraging results for these patients. In this retrospective study, we report the extended results of a sequential regimen of clofarabine, cytosine arabinoside, and RIC in 131 adults with active R/R myeloid disease at transplant. Conditioning consisted of clofarabine (30 mg/m

Indexed as

Hematopoietic Stem Cell TransplantationLeukemia, Myeloid, AcuteMyelodysplastic SyndromesTransplantation ConditioningAdolescentAdultAgedAllograftsAntineoplastic Combined Chemotherapy ProtocolsClofarabineCytarabineDisease-Free SurvivalFemaleHumansMaleMiddle AgedClofarabineCytarabineAcute myeloid leukemiaAllogeneic stem cell transplantationClofarabineReduced intensity conditioning regimenSequential regimen

Identifiers

PMID32564196
OpenAlexW3036606956

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.