ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2020
Emergency ambulatory outpatient management of immune-mediated hypophysitis.
Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Diagnostic criteria and proposed management of immune-related endocrinopathies following immune checkpoint inhibitor therapy for cancer.Endocrine connections · 2023Review
- Immune checkpoint inhibitor-mediated hypophysitis: no place like home.Clinical medicine (London, England) · 2023Article
- A Case of Abdominal Pain and Diarrhea Post Immunotherapy: Hypophysitis Associated with Immune Checkpoint Inhibitors.Journal of translational internal medicine · 2022Article
- Endocrine toxicity of cancer immunotherapy: clinical challenges.Endocrine connections · 2021Review
- Managing Ipilimumab-Induced Hypophysitis: Challenges and Current Therapeutic Strategies.Cancer management and research · 2020Review
Corrections and comments
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Authors and funding
6 authors.
Funding
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Abstract
purposeImmune-mediated hypophysitis is an important toxicity related to immune checkpoint inhibitors (ICI). Optimal management is associated with improved outcomes. It represents a wide spectrum of clinical presentations, and a proportion may be suitable for emergency ambulatory management.
methodsEmergency ambulatory management of patients presenting with clinical features and findings consistent with ICI-induced hypophysitis was considered at a tertiary cancer/endocrinology hospital. Suitable patients were initially investigated and treated in accordance with the UK emergency management guidelines for ICI induced hypophysitis. After an initial observation period of 4 h, patients were discharged with oral hydrocortisone (20, 10, 10 mg).
resultsAn initial cohort of 4 patients with emergency presentations of ICI-induced hypophysitis has been managed in an ambulatory fashion in the first 3 months. There were no 30-day readmissions.
conclusionCarefully selected emergency presentations with immune-mediated hypophysitis may be suitable for ambulatory management.
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