Evidence map›Paper›PMID 32564151›Full record

ArticleJournal of neurology2020

Midlife alcohol consumption and longitudinal brain atrophy: the PREVENT-Dementia study.

Michael J Firbank, John T O'Brien, Karen Ritchie, Katie Wells, Guy Williams, Li Su, Craig W Ritchie

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Neuroimaging-Derived Predicted Brain Age and Alcohol Use Among Community-Dwelling Older Adults.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2023
    Observational
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Michael J FirbankInstitute of Neuroscience, Newcastle University, Campus for Ageing and Vitality, Nuns Moor Road, Newcastle upon Tyne, NE4 5PL, UK. michael.firbank@ncl.ac.uk.ORCID http://orcid.org/0000-0002-9536-0185
John T O'BrienDepartment of Psychiatry, University of Cambridge, Level E4 Cambridge Biomedical Campus, Box 189, Cambridge, CB2 0SP, UK.
Karen RitchieINSERM, Montpellier, France.
Katie WellsThe Centre for Psychiatry, Imperial College London, 7th floor Commonwealth Building, Du Cane Road, London, W12 0NN, UK.
Guy WilliamsDepartment of Clinical Neurosciences and Wolfson Brain Imaging Centre, University of Cambridge, Cambridge Biomedical Campus, Cambridge, CB2 0SP, UK.
Li SuDepartment of Psychiatry, University of Cambridge, Level E4 Cambridge Biomedical Campus, Box 189, Cambridge, CB2 0SP, UK.
Craig W RitchieCentre for Dementia Prevention, University of Edinburgh, Edinburgh, UK.
University of Cambridge · GBImperial College London · GBInserm · FRNewcastle Hospitals - Campus for Ageing and Vitality · GBUniversity of Edinburgh · GB

Funding

Alzheimer's Association TriBEKa-17-519007The Dunhill Medical Trust R380R/1114
6 · The paper itself

Abstract

BACKGROUND AND

aimsConsensus is lacking on whether light to moderate consumption of alcohol compared to abstinence is neuroprotective. In this study, we investigated the relationship between self-reported alcohol use and brain volume change over 2 years in middle-aged subjects.

methodsA sample of 162 subjects (aged 40-59 at baseline) from the PREVENT-Dementia programme underwent MRI scans on two separate occasions (mean interval 734 days; SD 42 days). We measured longitudinal rates of brain atrophy using the FSL Siena toolbox, and change in hippocampal volume from segmentation in SPM.

resultsControlling for age and sex, there were no significant associations of either total brain, ventricular, or hippocampal volume change with alcohol consumption. Adjusting for lifestyle, demographic and vascular risk factors did not alter this.

conclusionsWe did not find any evidence of influence of alcohol consumption on changes in brain volume over a 2-year period in 40-60-year-olds.

Indexed as

DementiaMagnetic Resonance ImagingAlcohol DrinkingAtrophyBrainHumansLongitudinal StudiesMiddle AgedAlcoholAtrophyBrain volumeLongitudinalMid-lifeMRI

Identifiers

PMID32564151
PMCPMC7578123
OpenAlexW3035571672

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.