ArticlePsychopharmacology2020
Methionine mediates resilience to chronic social defeat stress by epigenetic regulation of NMDA receptor subunit expression.
Article in Psychopharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 15 citations in OpenAlex.
- Epigenetic Signatures of Social Defeat Stress Varying Duration.International journal of molecular sciences · 2025Article
- Article
- α-Ketoglutarate Is a Circulatory Exercise Factor That Promotes Learning and Memory Recall and Has Antidepressant Properties.Biological psychiatry global open science · 2025Article
- Historical loss weakens competitive behavior by remodeling ventral hippocampal dynamics.Cell discovery · 2025Article
- Unveiling chiral amino acid alterations and glycine dysregulation in late-life depression through targeted metabolomics.Frontiers in psychiatry · 2025Article
- Neurogenetic underpinnings of nicotine use severity: Integrating the brain transcriptomes and GWAS variants via network approaches.Psychiatry research · 2024Article
- Structural insights into the binding mechanism of Clr4 methyltransferase to H3K9 methylated nucleosome.Scientific reports · 2024Article
- RecQ dysfunction contributes to social and depressive-like behavior and affects aldolase activity in mice.Neurobiology of disease · 2023Article
- Autophagy regulates the release of exercise factors and their beneficial effects on spatial memory recall.Heliyon · 2023Article
- Interactive Effects of Methionine and Lead Intake on Cognitive Function among Chinese Adults.Nutrients · 2022Article
- Epigenetic mechanisms impacted by chronic stress across the rodent lifespan.Neurobiology of stress · 2022Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 3 countries.
Funding
Abstract
rationalePrevious studies suggested that methionine (Met) levels are decreased in depressed patients. However, whether the decrease in this amino acid is important for phenotypic behaviors associated with depression has not been deciphered.
objectiveThe response of individuals to chronic stress is variable, with some individuals developing depression and others becoming resilient to stress. In this study, our objective was to examine the effect of Met on susceptibility to stress.
methodsMale C57BL/6J mice were subjected to daily defeat sessions by a CD1 aggressor, for 10 days. On day 11, the behavior of mice was assessed using social interaction and open-field tests. Mice received Met 4 h before each defeat session. Epigenetic targets were assessed either through real-rime RTPCR or through Western Blots.
resultsMet did not modulate anxiety-like behaviors, but rather promoted resilience to chronic stress, rescued social avoidance behaviors and reversed the increase in the cortical expression levels of N-methyl-D-aspartate receptor (NMDAR) subunits. Activating NMDAR activity abolished the ability of Met to promote resilience to stress and to rescue social avoidance behavior, whereas inhibiting NMDAR did not show any synergistic or additive protective effects. Indeed, Met increased the cortical levels of the histone methyltransferase SETDB1, and in turn, the levels of the repressive histone H3 lysine (K9) trimethylation (me3).
conclusionsOur data indicate that Met rescues susceptibility to stress by inactivating cortical NMDAR activity through an epigenetic mechanism involving histone methylation.
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