ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2021
Clinical Features and Gut Microbiome of Asymptomatic Entamoeba histolytica Infection.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Review
- Multi-omics profiling and bile-acid exposure assays implicate a gut microbiome-parasite axis linked to persistent Entamoeba histolytica carriage.Gut pathogens · 2026Article
- Amebiasis as a neglected tropical disease: Current knowledge gaps and future directions.PLoS neglected tropical diseases · 2026Review
- The dual role of intestinal parasites in shaping human gut microbiota: distinguishing helminthic and protozoan dynamics.Gut pathogens · 2026Review
- Mixed intestinal protozoal infection masquerading as ulcerative colitis in advanced AIDS: a case report.Frontiers in medicine · 2026Article
- Gut microbiota-derived arginine metabolism mitigates intestinal ischemia-reperfusion injury.Journal of translational medicine · 2025Article
- Prevalence of Intestinal Amebiasis Among Saudi Residents Living in the Al-Baha Region, Saudi Arabia.Cureus · 2025Article
- Exploring virulence and stress response inMicrobiology spectrum · 2025Article
- Establishment and perturbation of human gut microbiome: common trends and variations between Indian and global populations.Gut microbiome (Cambridge, England) · 2024Review
- Amebiasis as a sexually transmitted infection: A re-emerging health problem in developed countries.Global health & medicine · 2023Review
- Diversity and Plasticity of Virulent Characteristics ofTropical medicine and infectious disease · 2023Review
- Frequency ofJournal of parasitology research · 2023Article
- Interleukin 10 (IL-10) Production and Seroprevalence ofPathogens (Basel, Switzerland) · 2022Article
- Identification and Semi-quantification of Protozoa from the Digestive System Microbiota of the Lobster Cockroach Nauphoeta cinerea Oliver, 1789 (Insecta:Blattaria).Acta parasitologica · 2022Article
- A rare case of extraintestinal amebiasis.BMC infectious diseases · 2022Article
- Identification of asymptomatic Entamoeba histolytica infection by a serological screening test: A cross-sectional study of an HIV-negative men who have sex with men cohort in Japan.PLoS neglected tropical diseases · 2022Article
- Parasites, Drugs and Captivity:Biology · 2021Article
- Epidemiology, species composition and genetic diversity of tetra- and octonucleated Entamoeba spp. in different Brazilian biomes.Parasites & vectors · 2021Article
- COVID-19 and Corticosteroids: Unfamiliar but Potentially Fatal Infections That Can Arise following Short-Course Steroid Treatment.The American journal of tropical medicine and hygiene · 2021Article
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9 authors.
Funding
Abstract
backgroundEntamoeba histolytica infection is a sexually transmitted disease in some developed countries. Asymptomatic infection often occurs and can be a source of transmission; however, limited data are available regarding the pathogenesis of E. histolytica.
methodsThis was a single-center, cross-sectional study. Specimens were prospectively collected from patients with clinically suspected cases. Entamoeba histolytica infection was defined as a case in which the identification of E. histolytica was confirmed by polymerase chain reaction (PCR) of a clinical specimen. Data from asymptomatic cases were compared with those from symptomatic invasive cases.
resultsSixty-four E. histolytica-infected cases, including 13 asymptomatic cases, were identified during the study period. Microbiological diagnosis was made by endoscopic sampling in 26.6% of these cases (17/64). Endoscopy identified macroscopically visible lesions in all cases; however, the sensitivity of histopathology on biopsy samples was low (45.5%) compared with PCR (94.7%). In asymptomatic cases, infection sites were limited around the proximal colon; moreover, trophozoites were frequently identified at infection sites whereas cystic forms were commonly detected in stools. Gut microbiome analyses showed more uniform composition in asymptomatic cases than in symptomatic invasive cases, which were represented by a relatively high abundance of Ruminococcaceae, Coriobacteriaceae, and Clostridiaceae, and a low abundance of Streptococcaceae.
conclusionsThese results indicate that the encystation and attenuation of E. histolytica are highly affected by the intestinal contents, including the gut microbiome.
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