ArticleThe Journal of thoracic and cardiovascular surgery2021
Predictors of nonuse of donation after circulatory death lung allografts.
Article in The Journal of thoracic and cardiovascular surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 30 citations in OpenAlex.
- Article
- Regional Variation in Transplant Utilization and Agonal Times among Donation after Circulatory Death Lung Donors in the United States.Clinical transplantation · 2026Article
- Lung transplantation from donation after circulatory death donors over 55 years old: A national analysis of outcomes and utilization.JHLT open · 2026Article
- Surgeons are apprehensive to use DCD lungs despite similar post-transplant outcomes: A 20-year UNOS retrospective analysis.JHLT open · 2025Article
- A Global Experience of Donation after Circulatory Death for Pediatric Lung Transplantation.Annals of the American Thoracic Society · 2025Article
- Lung Transplantation in Controlled Donation after Circulatory-Determination-of-Death Using Normothermic Abdominal Perfusion.Transplant international : official journal of the European Society for Organ Transplantation · 2024Review
- Limited cumulative experience with ex vivo lung perfusion is associated with inferior outcomes after lung transplantation.The Journal of thoracic and cardiovascular surgery · 2024Article
- The impact of thoracoabdominal normothermic regional perfusion on early outcomes in donation after circulatory death lung transplantation.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2023Article
- Early United States experience with lung donation after circulatory death using thoracoabdominal normothermic regional perfusion.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2023Article
- Selecting DCD Recipients Using Predictive Indices.Transplantation direct · 2023Article
- The utilization of nanopore targeted sequencing proves to be advantageous in the identification of infections present in deceased donors.Frontiers in microbiology · 2023Article
- Ex-vivo lung perfusion therapies: do they add value to organ donation?Current opinion in organ transplantation · 2022Review
- Trends in Donation After Circulatory Death in Lung Transplantation in the United States: Impact Of Era.Transplant international : official journal of the European Society for Organ Transplantation · 2022Article
- Donation after circulatory death donors in lung transplantation.Journal of thoracic disease · 2021Review
- A three-tier system for evaluation of organ procurement organizations' willingness to pursue and utilize nonideal donor lungs.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2021Article
- Predictors of Older Donor Lung Use: Are We Too Good at Saying No?The Annals of thoracic surgery · 2020Article
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8 authors at 3 institutions in 2 countries.
Funding
Abstract
objectiveDespite growing evidence of comparable outcomes in recipients of donation after circulatory death and donation after brain death donor lungs, donation after circulatory death allografts continue to be underused nationally. We examined predictors of nonuse.
methodsAll donors who donated at least 1 organ for transplantation between 2005 and 2019 were identified in the United Network for Organ Sharing registry and stratified by donation type. The primary outcome of interest was use of pulmonary allografts. Organ disposition and refusal reasons were evaluated. Multivariable regression modeling was used to assess the relationship between donor factors and use.
resultsA total of 15,458 donation after circulatory death donors met inclusion criteria. Of 30,916 lungs, 3.7% (1158) were used for transplantation and 72.8% were discarded primarily due to poor organ function. Consent was not requested in 8.4% of donation after circulatory death offers with donation after circulatory death being the leading reason (73.4%). Nonuse was associated with smoking history (P < .001), clinical infection with a blood source (12% vs 7.4%, P = .001), and lower PaO
conclusionsNontransplantation of donation after circulatory death lungs was associated with potentially modifiable predonation factors, including organ procurement organizations' consenting behavior, and donor factors, including hypoxemia. Interventions to increase consent and standardize donation after circulatory death donor management, including selective use of ex vivo lung perfusion in the setting of hypoxemia, may increase use and the donor pool.
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