ArticleBMC neurology2020
Amino acid metabolism, lipid metabolism, and oxidative stress are associated with post-stroke depression: a metabonomics study.
Article in BMC neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Sex as a biological variable in determining the metabolic changes influencing acute ischemic stroke outcomes-Where is the data: A systematic review.Frontiers in neurology · 2022Pooled it
- Evaluation of MassFrontier, MetFrag, MS-FINDER, and SIRIUS for Metabolite Annotation Using an Experimental LC-HRMS Dataset.Biomedicines · 2026Article
- Insights into the interplay between stroke and depression through lipid metabolism-related diagnostic genes.Molecular brain · 2026Article
- The Role of Gut Bacteria and Plasma Metabolites in Predicting Post-Stroke Depression in Patients with Acute Ischemic Stroke.Current neuropharmacology · 2026Article
- Investigating the causal relationship between genetically determined metabolites and ischemic stroke functional outcomes: a Mendelian randomization study.Cardiovascular diagnosis and therapy · 2025Article
- The impact of climatic factors on negative sentiments: An analysis of human expressions from X platform in Germany.iScience · 2025Article
- Novel Metabolites as Potential Indicators of Recovery After Large Vessel Occlusion Stroke: A Pilot Study.Neurology international · 2025Article
- Characteristics of Gut Microbiota and Plasma Metabolites in Patients with Post-Stroke Depression.Neuropsychiatric disease and treatment · 2025Article
- A fundamental study on postmortem submersion interval estimation by metabolomics analyzing of gastrocnemius muscle from submersed rat models in freshwater.International journal of legal medicine · 2024Article
- Associations between Life's Essential 8 and post-stroke depression and all-cause mortality among US adults.European journal of medical research · 2024Article
- Metabolic signatures and potential biomarkers of sarcopenia in suburb-dwelling older Chinese: based on untargeted GC-MS and LC-MS.Skeletal muscle · 2024Article
- Untargeted Plasma Metabolomic Profiling in Patients with Depressive Disorders: A Preliminary Study.Metabolites · 2024Article
- Relationship between oxidative balance score and post-stroke depression: insights from the NHANES 2005-2018 cross-sectional study.Frontiers in neurology · 2024Article
- Metabolic Alterations and Related Biological Functions of Post-Stroke Depression in Ischemic Stroke Patients.Neuropsychiatric disease and treatment · 2023Article
- Electroacupuncture Ameliorates Depression-Like Behaviors in Post-Stroke Rats via Activating AMPK-Mediated Mitochondrial Function.Neuropsychiatric disease and treatment · 2023Article
- Metabolic Regulation Effect and Potential Metabolic Biomarkers of Pre-Treated Delphinidin on Oxidative Damage Induced by Paraquat in A549 Cells.Foods (Basel, Switzerland) · 2022Article
- Alteration of Glycerophospholipid Metabolism in Hippocampus of Post-stroke Depression Rats.Neurochemical research · 2022Article
- Peripheral blood and urine metabolites and biological functions in post-stroke depression.Metabolic brain disease · 2022Article
- Dictyophora Polysaccharide Attenuates As-Mediated PINK1/Parkin Pathway-Induced Mitophagy in L-02 Cell through Scavenging ROS.Molecules (Basel, Switzerland) · 2022Article
- Does urinary metabolite signature act as a biomarker of post-stroke depression?Frontiers in psychiatry · 2022Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundPost-stroke depression (PSD) is a mood disorder characterized by depression and anhedonia caused by stroke. Metabolomics identified metabolites associated with PSD, but previous studies are based on gas chromatography (GC)/mass spectrometry (MS). This study aimed to perform a liquid chromatography (LC)-MS-based metabolomics study of the plasma metabolite profiles between patients with PSD and controls.
methodsThis was a prospective study of patients with stroke enrolled between July and December 2017 at the Second Affiliated Hospital of Nanchang University. Patients were grouped as Hamilton Depression Rating Scale > 7 (PSD) or < 7 (controls). Metabonomics profiling of plasma sampled was conducted by LC-MS. By combining multivariable and univariable statistical analyses, significant differential metabolites between the two groups were screened. The threshold for significant differences was VIP ≥1 and P < 0.05. Log
resultsThere were no significant difference with respect to age, NIHSS score, and MMSE between the two groups (all P > 0.05). There were six differential metabolites between the PSD and stroke groups, of which three metabolites were increased and three were decreased. Compared with the control group, p-chlorophenylalanine (Log
conclusionPlasma metabolomics showed that amino acid metabolism (phenylacetyl glutamine, p-chlorophenylalanine, trimethylglycine), lipid metabolism (DHA, palmitic acid, trimethylglycine), and oxidative stress (DHA, palmitic acid, trimethylglycine) were associated with PSD. These results could help to reveal the pathophysiological mechanism of PSD and eventually identify treatment targets.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.