Evidence map›Paper›PMID 32563185›Full record

ArticlePediatric research2020

High concentrations of urinary ethanol metabolites in neonatal intensive care unit infants.

Matthew P Stefanak, Faeq Al-Mudares, Dina El-Metwally, Jace W Jones, Maureen A Kane, Cynthia F Bearer

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Article in Pediatric research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Matthew P StefanakDepartment of Pediatrics, University of Maryland School of Medicine, Baltimore, MD, USA.
Faeq Al-MudaresDepartment of Pediatrics, University of Maryland School of Medicine, Baltimore, MD, USA.
Dina El-MetwallyDepartment of Pediatrics, University of Maryland School of Medicine, Baltimore, MD, USA.
Jace W JonesMass Spectrometry Center, University of Maryland School of Pharmacy, Baltimore, MD, USA.
Maureen A KaneMass Spectrometry Center, University of Maryland School of Pharmacy, Baltimore, MD, USA.
Cynthia F BearerDepartment of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, OH, USA. cynthia.bearer@UHhospitals.org.
University of Maryland, Baltimore · USCase Western Reserve University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInfants in the neonatal intensive care unit may be exposed to ethanol via medications that contain ethanol as an excipient and through inhalation of ethanol vapor from hand sanitizers. We hypothesized that both pathways of exposure would result in elevated urinary biomarkers of ethanol.

methodsUrine samples were collected from infants in incubators and in open cribs. Two ethanol metabolites, ethyl sulfate (EtS) and ethyl glucuronide (EtG), were quantified in infants' urine.

resultsA subset of infants both in incubators and open cribs had ethanol biomarkers greater than the cutoff concentration that identifies adult alcohol consumption. These concentrations were associated with the infant having received an ethanol-containing medication on the day of urine collection. When infants who received an ethanol-containing medication were excluded from analysis, there was no difference in ethanol biomarker concentrations between the incubator and crib groups.

conclusionsSome infants who received ethanol-containing medications had concentrations of ethanol biomarkers that are indicative of adult alcohol consumption, suggesting potential exposure via ethanol excipients. IMPACT: Infants and newborns in the neonatal intensive care unit are exposed to concerning amounts of ethanol. No one has shown exposure to ethanol in these infants before this study. The impact is that better understanding of the excipients in medications given to patients in the NICU is needed. When physicians order medications in the NICU, the amount of excipient needs to be indicated.

Indexed as

Intensive Care Units, NeonatalBiomarkersChromatography, LiquidEthanolFemaleGlucuronatesHand SanitizersHumansIncubatorsInfantInfant, NewbornInfant, PrematureIntensive Care, NeonatalMaleMass SpectrometrySulfuric Acid EstersBiomarkersdiethyl sulfateEthanolethyl glucuronideGlucuronatesHand SanitizersSulfuric Acid Esters

Identifiers

PMID32563185
OpenAlexW3036211515

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.