Evidence map›Paper›PMID 32563126›Full record

ArticleJournal of neuroimmunology2020

Searching for autoimmune encephalitis: Beware of normal CSF.

Julien Hébert, Priti Gros, Sarah Lapointe, Fatima S Amtashar, Claude Steriade, Catherine Maurice, Richard A Wennberg, Gregory S Day, David F Tang-Wai

Open access · greenAbstract readMulticenter Study
In one paragraph

Article in Journal of neuroimmunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
3.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 58 citations in OpenAlex.

  1. Article
  2. Neuronal Antibodies in Patients With Atypical Parkinsonism.Neurology(R) neuroimmunology & neuroinflammation · 2026
    Observational
  3. Article
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  5. Review
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  11. Review
  12. Article
  13. Observational
  14. Article
  15. Article
  16. Review
  17. MR Imaging Findings in a Large Population of Autoimmune Encephalitis.AJNR. American journal of neuroradiology · 2023
    Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Julien HébertUniversity of Toronto, Division of Neurology, Canada.
Priti GrosUniversity of Toronto, Division of Neurology, Canada.
Sarah LapointeUniversity of Toronto, Division of Neurology, Canada; University Health Network, Toronto, Canada.
Fatima S AmtasharWashington University School of Medicine, Dept of Neurology, MO, USA.
Claude SteriadeNew York University Langone Comprehensive Epilepsy Center, NY, USA.
Catherine MauriceUniversity of Toronto, Division of Neurology, Canada; University Health Network, Toronto, Canada.
Richard A WennbergUniversity of Toronto, Division of Neurology, Canada; University Health Network, Toronto, Canada.
Gregory S DayMayo Clinic Florida, Department of Neurology, Jacksonville, FL, USA.
David F Tang-WaiUniversity of Toronto, Division of Neurology, Canada; University Health Network, Toronto, Canada. Electronic address: david.tang-wai@uhn.ca.
University of Toronto · CAUniversity Health Network · CAJacksonville College · USNYU Langone Health · USWashington University in St. Louis · US

Funding

Rapidly Progressive Dementia: Moving Beyond CJDK23AG064029 · NIA · WASHINGTON UNIVERSITY · PI DAY, GREGORY SCOTT · 2019 to 2023
$811k
NIA NIH HHS K23 AG064029
6 · The paper itself

Abstract

objectiveTo determine the prevalence of cerebrospinal fluid (CSF) markers associated with inflammation (i.e., elevated white blood cell count, protein concentration, and CSF-specific oligoclonal bands) in patients with early active autoimmune encephalitis (AE).

methodsCSF characteristics, including WBC count, protein concentration, and oligoclonal banding, were analyzed in patients diagnosed with AE at two tertiary care centers.

resultsNinety-five patients were included in the study. CSF white blood cell counts and protein levels were within normal limits for 27% (CI

conclusionsWhite blood cell counts and protein levels were within normal limits in the CSF of a substantial proportion of patients with early active AE. Inclusion of CSF oligoclonal banding identified a higher proportion of patients with an inflammatory CSF profile, especially when CSF was sampled early in the disease process.

Indexed as

AdolescentAdultAgedAged, 80 and overBiomarkersEncephalitisFemaleHashimoto DiseaseHumansInflammation MediatorsMaleMiddle AgedProspective StudiesYoung AdultBiomarkersInflammation MediatorsAutoimmune diseasesAutoimmune encephalitisCerebrospinal fluidDiagnostic studiesEncephalitis

Identifiers

PMID32563126
PMCPMC7376817
OpenAlexW3033920501

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.