ReviewEnvironmental toxicology and pharmacology2020
Dual function of sialic acid in gastrointestinal SARS-CoV-2 infection.
Review in Environmental toxicology and pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
- Gastrointestinal Infiltration in Influenza Virus Infection: Mechanisms and Clinical Insights.Viruses · 2025Review
- Host Membranes as Drivers of Virus Evolution.Viruses · 2023Article
- Convergent Evolution Dynamics of SARS-CoV-2 and HIV Surface Envelope Glycoproteins Driven by Host Cell Surface Receptors and Lipid Rafts: Lessons for the Future.International journal of molecular sciences · 2023Review
- A Vaccine Strategy Based on the Identification of an Annular Ganglioside Binding Motif in Monkeypox Virus Protein E8L.Viruses · 2022Article
- Evaluation of serum total sialic acid in moderate COVID-19 patients with and without gastrointestinal tract manifestations.Tissue & cell · 2022Article
- The role of cell surface sialic acids for SARS-CoV-2 infection.Glycobiology · 2021Review
- Suppression of O-Linked Glycosylation of the SARS-CoV-2 Spike by Quaternary Structural Restraints.Analytical chemistry · 2021Article
- The effect of environmental diesel exhaust pollution on SARS-CoV-2 infection: The mechanism of pulmonary ground glass opacity.Environmental toxicology and pharmacology · 2021Review
- Current opinion in neurological manifestations of SARS-CoV-2 infection.Current opinion in toxicology · 2021Review
- Recombinant SARS-CoV-2 S Protein Binds to Glycans of the Lactosamine Family in vitro.Biochemistry. Biokhimiia · 2021Article
- Subtle Influence of ACE2 Glycan Processing on SARS-CoV-2 Recognition.Journal of molecular biology · 2021Article
- Leveraging coronavirus binding to gangliosides for innovative vaccine and therapeutic strategies against COVID-19.Biochemical and biophysical research communications · 2021Article
- The effect of environmental pollution on immune evasion checkpoints of SARS-CoV-2.Environmental toxicology and pharmacology · 2021Review
- Targeting Crucial Host Factors of SARS-CoV-2.ACS infectious diseases · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent analysis concerning the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)- angiotensin converting enzyme (ACE) receptor interaction in enterocytes, the definition of gut-lung axis, as well as the molecular basis of sialic acid-related dual recognition concept in gastrointestinal SARS-CoV-2 infection, have brought a new perspective to potential therapeutic targets. In this review evolving research and clinical data on gastrointestinal SARS-CoV-2 infection are discussed in the context of viral fusion and entry mechanisms, focusing on the different triggers used by coronaviruses. Furthermore, it is emphasized that the viral spike protein is prevented from binding gangliosides, which are composed of a glycosphingolipid with one or more sialic acids, in the presence of chloroquine or hydroxychloroquine. In gastrointestinal SARS-CoV-2 infection the efficiency of these repositioned drugs is debated.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.