Evidence map›Paper›PMID 32562660›Full record

ReviewNeuron2020

What Is the Relationship between Pain and Emotion? Bridging Constructs and Communities.

Gadi Gilam, James J Gross, Tor D Wager, Francis J Keefe, Sean C Mackey

Abstract readReview
In one paragraph

Review in Neuron, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

74 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Sleep and affect: A conceptual review.Sleep medicine reviews · 2022
    Pooled it
  4. Pooled it
  5. Pooled it
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  8. Observational
  9. Article
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  13. Review
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  19. Continuous, Contactless, and Multimodal Pain Assessment During Surgical Interventions.IEEE open journal of engineering in medicine and biology · 2026
    Article
  20. Article

14 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Gadi GilamDepartment of Anesthesiology, Perioperative, and Pain Medicine, Division of Pain Medicine, Stanford University School of Medicine, 1070 Arastradero Road, Suite 200, MC 5596, Palo Alto, CA 94304, USA. Electronic address: gadig@stanford.edu.
James J GrossDepartment of Psychology, Stanford University, Stanford, CA 94305, USA.
Tor D WagerDepartment of Psychological and Brain Sciences, Dartmouth College, HB 6207, Moore Hall, Hanover, NH 03755, USA.
Francis J KeefeDepartment of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27705, USA.
Sean C MackeyDepartment of Anesthesiology, Perioperative, and Pain Medicine, Division of Pain Medicine, Stanford University School of Medicine, 1070 Arastradero Road, Suite 200, MC 5596, Palo Alto, CA 94304, USA.

Funding

Wake Forest NCORP Research BaseUG1CA189824 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Emily Van Meter Dressler, GLENN J LESSER · 2014 to 2026
$57.9M
Palliative Care Research Cooperative Group (PCRC): Refinement and ExpansionU2CNR014637 · NINR · UNIVERSITY OF COLORADO DENVER · PI HANSON, LAURA C · 2018 to 2022
$8.6M
The Neural Bases of Placebo Effects and their Relation to Regulatory ProcessesR01MH076136 · NIMH · UNIVERSITY OF COLORADO · PI WAGER, TOR D. · 2007 to 2023
$8.5M
Stanford CAM Center for Chronic Back PainP01AT006651 · NCCIH · STANFORD UNIVERSITY · PI MACKEY, SEAN C · 2011 to 2018
$8.2M
Dynamic brain representations underlying emotional experienceR01MH116026 · NIMH · DARTMOUTH COLLEGE · PI CHANG, LUKE JOSEPH · 2018 to 2025
$4.9M
Brain and Genetic Predictors of Individual Differences in Pain and Placebo AnalgesiaR01DA046064 · NIDA · UNIVERSITY OF COLORADO · PI FRIEDMAN, NAOMI P., WAGER, TOR D. · 2018 to 2022
$3.2M
Roybal Center Pilot CoreP30AG064201 · NIA · DUKE UNIVERSITY · PI COLON-EMERIC, CATHLEEN S, STRAUMAN, TIMOTHY J · 2019 to 2023
$3.2M
fMRI-based Biomarkers for Multiple Components of PainR01DA035484 · NIDA · UNIVERSITY OF COLORADO · PI WAGER, TOR D. · 2013 to 2017
$3.1M
Characterization of central pain mechanisms using simultaneous spinal cord-brain functional imagingR01NS109450 · NINDS · STANFORD UNIVERSITY · PI GLOVER, GARY H, MACKEY, SEAN C · 2018 to 2022
$2.9M
Reducing the Transition from Acute to Chronic Musculoskeletal Pain among Older AdultsR01AG058702 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MEYER, MICHELLE · 2019 to 2023
$2.6M
The neural bases of placebo effects and their relation to regulatory processesR37MH076136 · NIMH · DARTMOUTH COLLEGE · PI TOR D. WAGER · 2024 to 2026
$2.4M
Neuroimaging and Mentoring in Translational Pain ResearchK24DA029262 · NIDA · STANFORD UNIVERSITY · PI MACKEY, SEAN C · 2010 to 2019
$1.9M
NCCIH NIH HHS P01 AT006651NCI NIH HHS UG1 CA189824NIA NIH HHS P30 AG064201NIA NIH HHS R01 AG058702NIDA NIH HHS K24 DA029262NIDA NIH HHS R01 DA035484NIDA NIH HHS R01 DA046064NIMH NIH HHS R01 MH076136NIMH NIH HHS R01 MH116026NIMH NIH HHS R37 MH076136NINDS NIH HHS R01 NS109450NINR NIH HHS U2C NR014637
6 · The paper itself

Abstract

Although pain is defined as a sensory and emotional experience, it is traditionally researched and clinically treated separately from emotion. Conceptual and mechanistic relationships between these constructs highlight the need for better understanding of their bi-directional influences and the value of bridging the pain and emotion research and clinical communities.

Indexed as

BrainEmotionsHumansPainaffectbrainchronic painemotioninteroceptionmental healthnociceptionnoxiouspainsubjective experience

Identifiers

PMID32562660
PMCPMC7578761

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.