ArticleBrain and behavior2020
The functional networks of a novel environment: Neural activity mapping in awake unrestrained rats using positron emission tomography.
Article in Brain and behavior, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 17 citations in OpenAlex.
- Adolescent ΔPharmaceuticals (Basel, Switzerland) · 2026Article
- Neurotensin in the extended amygdala maintains wakefulness in novel environments.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Refining drug screening with automated home cage monitoring: a crossover study in socially housed rats.Frontiers in toxicology · 2026Article
- PGx-BasedCurrent neuropharmacology · 2026Article
- Experiencing Novelty in Adolescence and the Influence of Prior Novelty-Related Experiences on Adult Behavioral Outcomes in Wistar Han Rats.Animals : an open access journal from MDPI · 2025Article
- Cocaine self-administration attenuates brain glucose metabolism and functional connectivity in rats.PloS one · 2025Article
- Laminar multi-contrast fMRI at 7T allows differentiation of neuronal excitation and inhibition underlying positive and negative BOLD responses.medRxiv : the preprint server for health sciences · 2024Article
- Exercise Influences the Brain's Metabolic Response to Chronic Cocaine Exposure in Male Rats.Journal of personalized medicine · 2024Article
- Laminar multi-contrast fMRI at 7T allows differentiation of neuronal excitation and inhibition underlying positive and negative BOLD responses.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Exercise Modifies the Brain Metabolic Response to Chronic Cocaine Exposure Inhibiting the Stria Terminalis.Brain sciences · 2023Article
- Exercise Modulates Brain Glucose Utilization Response to Acute Cocaine.Journal of personalized medicine · 2022Article
- Changes in the Behavior and Body Weight of Mature, Adult Male Wistar Han Rats after Reduced Social Grouping and Social Isolation.Journal of the American Association for Laboratory Animal Science : JAALAS · 2022Article
- Caffeine-Induced Acute and Delayed Responses in Cerebral Metabolism of Control and Schizophrenia-Like Wisket Rats.International journal of molecular sciences · 2022Article
- Brain Mapping the Effects of Chronic Aerobic Exercise in the Rat Brain Using FDG PET.Journal of personalized medicine · 2022Article
- The influence of continuous prenatal exposure to valproic acid on physical, nociceptive, emotional and psychomotor responses during adolescence in mice: Dose-related effects within sexes.Frontiers in behavioral neuroscience · 2022Article
- Hypothalamic perifornical Urocortin-3 neurons modulate defensive responses to a potential threat stimulus.iScience · 2021Article
- The functional networks of a novel environment: Neural activity mapping in awake unrestrained rats using positron emission tomography.Brain and behavior · 2020Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
introductionNovel environment stimulation is thought to have an important role in cognitive development and has been shown to encourage exploratory behavior in rats. However, psychopathology or perceived danger or stress can impede this exploratory drive. The balance between brain circuits controlling the exploratory drive elicited by a novel environment, and the avoidance response to stressors, is not well understood.
methodsUsing positron emission tomography (PET) and the glucose analog [
resultsExposure to the novel environment increased BGluM in regions associated with vision (visual cortex), motor function and motivated behavior (striatum and motor cortex), and anxiety (stria terminalis), and decreased BGluM in regions associated with auditory processing (auditory cortex, insular cortex, inferior colliculus), locomotor activity (globus pallidus, striatum, motor cortex, ventral thalamic nucleus), spatial navigation (retrosplenial cortex), and working memory (hippocampus, cingulate cortex, prelimbic cortex, orbitofrontal cortex).
conclusionThese results suggest that the novel cage is a stressful environment that inhibits activity in brain regions associated with exploratory behavior. Patterns of inhibition in the novel cage also support the proposed rat default mode network, indicating that animals are more cognitively engaged in this environment. Additionally, these data support the unique capability of combining FDG-PET with psychopharmacology experiments to examine novelty seeking and brain activation in the context of decision making, risk taking, and cognitive function more generally, along with response to environmental or stress challenges.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.