ArticleJournal of diabetes investigation2021
Effect of the FreeStyle Libre™ flash glucose monitoring system on glycemic control in individuals with type 2 diabetes treated with basal-bolus insulin therapy: An open label, prospective, multicenter trial in Japan.
Article in Journal of diabetes investigation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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The trial behind it
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- Continuous glucose monitoring in type 2 diabetes: Evidence for glycaemic metrics and patient-reported outcomes.Diabetic medicine : a journal of the British Diabetic Association · 2026Pooled it
- Continuous glucose monitoring in type 2 diabetes: a systematic review of barriers and opportunities for care improvement.International journal for quality in health care : journal of the International Society for Quality in Health Care · 2025Pooled it
- Association between continuous glucose monitoring metrics and diabetic retinopathy and albuminuria among Japanese individuals with type 1 diabetes.Journal of diabetes investigation · 2026Article
- Article
- "What is it like to live with a CGM?": A qualitative study on type 1 diabetes patients' experiences.BMC health services research · 2025Article
- Consensus statement on novel glucose-related metrics obtained through advanced medical devices: English version.Diabetology international · 2025Article
- The efficacy of intermittent scanning continuous glucose monitoring in the elderly: A case-control study.Diabetes, obesity & metabolism · 2025Observational
- Intermittent Use of Flash Glucose Monitoring Improves Glycemic Control in Chinese Older Patients with Type 2 Diabetes Mellitus.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- Trends in Intermittent Scanning Continuous Glucose Monitoring Usage in The Netherlands-An Opportunity for Elderly Individuals with Diabetes.Journal of clinical medicine · 2024Article
- The era of continuous glucose monitoring and its expanded role in type 2 diabetes.Journal of diabetes investigation · 2023Article
- Advances in insulin therapy from discovery to β-cell replacement.Journal of diabetes investigation · 2023Article
- Status of glycemic excursions and hypoglycemia in patients with type 1 diabetes 2 months after first initiation of intermittently scanned continuous glucose monitoring: a pilot study.Diabetology international · 2022Article
- The Effects of Imeglimin on the Daily Glycemic Profile Evaluated by Intermittently Scanned Continuous Glucose Monitoring: Retrospective, Single-Center, Observational Study.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2022Article
- Effect of the FreeStyle Libre™ flash glucose monitoring system on glycemic control in individuals with type 2 diabetes treated with basal-bolus insulin therapy: An open label, prospective, multicenter trial in Japan.Journal of diabetes investigation · 2021Article
- Association between Flash Glucose Monitors and A1C: A Retrospective Pre-Post Analysis.Innovations in pharmacy · 2021Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
Abstract
AIMS/
introductionWe investigated the effect of FreeStyle Libre MATERIALS AND
methodsThis prospective, 90-day single-arm study enrolled 94 adults with type 2 diabetes treated with insulin. A 14-day masked baseline phase was followed by an 11-week treatment phase during which participants used the device to monitor glucose levels. The primary end-point was time spent in hypoglycemia (<70 mg/dL) for baseline versus study end (days 76-90). Secondary end-points included other measures of glycemic control, along with patient satisfaction using the Japanese Diabetes Treatment and Satisfaction Questionnaire.
resultsTime spent in hypoglycemia was low at baseline (0.51 ± 0.93 h/day) and did not significantly decrease at study end (0.47 ± 0.63 h/day, P = 0.6354). Time in range, time in hyperglycemia and estimated A1c all improved versus baseline (by +1.7 ± 3.0 h/day, -1.6 ± .4 h/day and -0.4 ± 0.8%, respectively, P < 0.0001 in each). Finger stick tests fell from 2.9 ± 1.3 to 1.9 ± 1.4/day, and mean scanning frequency during the intervention phase was 11.3/day. The mean treatment satisfaction score increased by 11.8 ± 5.3 (P < 0.0001). Two severe hypoglycemia-related adverse events were reported; one of which was possibly related to the device. Three participants reported mild device-related skin trauma, site discomfort or subcutaneous bleeding.
conclusionsUse of FreeStyle Libre by Japanese type 2 patients diabetes treated with basal-bolus insulin therapy showed a low baseline of hypoglycemia, and enabled improved glycemic control and treatment satisfaction.
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