ArticleJournal of clinical laboratory analysis2020
Hsa_circ_0023642 promotes proliferation, invasion, and migration of gastric cancer by sponging microRNA-223.
Article in Journal of clinical laboratory analysis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 8 citations in OpenAlex.
- Biological roles and molecular mechanism of circular RNAs in epithelial-mesenchymal transition of gastrointestinal malignancies.Oncology research · 2025Review
- Hsa_circ_0005230 is up-regulated and promotes gastric cancer cell invasion and migration via regulating the miR-1299/RHOT1 axis.Bioengineered · 2022Article
- Hsa_circ_0003195 as a biomarker for diagnosis and prognosis of gastric cancer.International journal of clinical oncology · 2022Article
- Reduced expression of circRNA hsa_circ_001888 in gastric cancer and its clinical significance.Journal of clinical laboratory analysis · 2021Article
- Circular RNA hsa_circ_0001874 is an indicator for gastric cancer.Journal of clinical laboratory analysis · 2021Article
- CircCSNK1G1 Contributes to the Tumorigenesis of Gastric Cancer by Sponging miR-758 and Regulating ZNF217 Expression.Cancer management and research · 2021Article
- Circular RNAs in gastrointestinal cancer: Current knowledge, biomarkers and targeted therapy (Review).International journal of molecular medicine · 2020Review
- Hsa_circ_0023642 promotes proliferation, invasion, and migration of gastric cancer by sponging microRNA-223.Journal of clinical laboratory analysis · 2020Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundCircular RNAs (circRNAs) have a closed-loop structure and are associated with various cellular biological processes, including carcinogenesis and cancer development. However, our knowledge of circRNAs in gastric cancer (GC) remains limited. Thus, this study aimed to investigate the role and underlying molecular mechanisms of hsa_circ_0023642 in GC. MATERIALS AND
methodsBioinformatic analysis revealed that hsa_circ_0023642 was upregulated in GC. Chromogenic in situ hybridization (CISH) chips was used to explore the relationship between the expression of hsa_circ_0023642 and the malignant degree, clinical stage, and prognosis of patients with GC. The role of hsa_circ_0023642 in GC was assessed in vitro, and biotin-coupled RNA pull-down was conducted to evaluate the interaction in between hsa_circ_0023642 and miR-223.
resultsThe current study showed that hsa_circ_0023642 was upregulated in GC and presented a high positive correlation with the malignant progression of GC. In addition, in vitro experiments showed that the silencing of hsa_circ_0023642 in GC cell lines MKN-45 and SGC-7901 significantly reduced the proliferation, invasion, and migration of GC cells. We confirmed that hsa_circ_0023642 could serve as a sponge of miR-223, subsequently promoting GC progression.
conclusionThis study shows that the upregulation of hsa_circ_0023642 affects the malignant progression, clinical stage, and prognosis of GC which provides a new molecular target for the therapy of GC.
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