Evidence map›Paper›PMID 32562269›Full record

ArticleBritish journal of pharmacology2020

CB

Gilson Goncalves Dos Santos, Ruihui Li, Melissa Pui Een Ng, Julia Borges Paes Lemes, Willians Fernando Vieira, Istvan Nagy, Cláudia Herrera Tambeli, Carlos Amilcar Parada

Open access · bronzeAbstract read
In one paragraph

Article in British journal of pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

  1. Metamizole: Indications and Risks.Deutsches Arzteblatt international · 2026
    Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Pathology of pain and its implications for therapeutic interventions.Signal transduction and targeted therapy · 2024
    Review
  7. Review
  8. Kinin BPharmaceutics · 2023
    Article
  9. Article
  10. Article
  11. CBBritish journal of pharmacology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Gilson Goncalves Dos SantosPain Studies Lab - Department of Structural and Functional Biology, Institute of Biology, University of Campinas - UNICAMP, Campinas, Brazil.ORCID 0000-0002-2704-3006
Ruihui LiNociception Group, Section of Anaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Imperial College London, London, UK.ORCID 0000-0003-2892-6086
Melissa Pui Een NgNociception Group, Section of Anaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Imperial College London, London, UK.ORCID 0000-0001-9700-4910
Julia Borges Paes LemesPain Studies Lab - Department of Structural and Functional Biology, Institute of Biology, University of Campinas - UNICAMP, Campinas, Brazil.ORCID 0000-0003-2212-6803
Willians Fernando VieiraPain Studies Lab - Department of Structural and Functional Biology, Institute of Biology, University of Campinas - UNICAMP, Campinas, Brazil.ORCID 0000-0003-3022-7997
Istvan NagyNociception Group, Section of Anaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Imperial College London, London, UK.ORCID 0000-0003-3475-6108
Cláudia Herrera TambeliPain Studies Lab - Department of Structural and Functional Biology, Institute of Biology, University of Campinas - UNICAMP, Campinas, Brazil.ORCID 0000-0001-5566-710X
Carlos Amilcar ParadaPain Studies Lab - Department of Structural and Functional Biology, Institute of Biology, University of Campinas - UNICAMP, Campinas, Brazil.ORCID 0000-0001-5209-8853
Universidade Estadual de Campinas (UNICAMP) · BRImperial College London · GB

Funding

Coordination of Improvement of Higher Education Personnel (CAPES), BrazilSao Paulo Research Foundation - Fapesp 2017/2345-0
6 · The paper itself

Abstract

background and purposeWhile dipyrone is a widely used analgesic, its mechanism of action is not completely understood. Recently, we have reported that the dipyrone metabolite 4-aminoantipyrine (4-AA) reduces PGE EXPERIMENTAL APPROACH: The effect of local administration of 4-AA (160 μg per paw) on capsaicin (0.12 μg per paw) injection-induced pain-related behaviour and 4-AA's effect on 500-nM capsaicin-induced changes in intracellular calcium concentration ([Ca KEY

results4-AA reduced capsaicin-induced nociceptive behaviour in naive and inflamed conditions through CB CONCLUSION AND IMPLICATIONS: CB

Indexed as

DipyroneTRPV Cation ChannelsAnalgesicsCapsaicinGanglia, SpinalSensory Receptor CellsAnalgesicsCapsaicinDipyroneTRPV Cation Channelscalcium imagingCB1dipyronedorsal root ganglionTRPA1TRPV1

Identifiers

PMID32562269
PMCPMC7520441
OpenAlexW3035783703

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.