Evidence map›Paper›PMID 32562251›Full record

ArticleBiomolecular NMR assignments2020

Eleni Makraki, Marta G Carneiro, Alex Heyam, A B Eiso, Gregg Siegal, Roderick E Hubbard

Erratum issuedOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecular NMR assignments, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 61% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 3 countries.

Eleni MakrakiYSBL, Department of Chemistry, University of York, Heslington, York, UK.
Marta G CarneiroZoBio BV, J.H. Oortweg 19, 2333 CH, Leiden, The Netherlands. mcarneiro@zobio.com.ORCID 0000-0001-7827-1685
Alex HeyamYSBL, Department of Chemistry, University of York, Heslington, York, UK.
A B EisoZoBio BV, J.H. Oortweg 19, 2333 CH, Leiden, The Netherlands.
Gregg SiegalZoBio BV, J.H. Oortweg 19, 2333 CH, Leiden, The Netherlands.
Roderick E HubbardYSBL, Department of Chemistry, University of York, Heslington, York, UK. roderick.hubbard@york.ac.uk.
University of York · GBGranta Design (United Kingdom) · GBSaint Louis Zoo · USVrije Universiteit Amsterdam · NL

Funding

BBSRC BB/N008332/1European Union's Horizon2020 MSCA Programme 675899Wellcome Trust
6 · The paper itself

Abstract

β-glucosidases have received considerable attention due to their essential role in bioethanol production from lignocellulosic biomass. β-glucosidase can hydrolyse cellobiose in cellulose degradation and its low activity has been considered as one of the main limiting steps in the process. Large-scale conversions of cellulose therefore require high enzyme concentration which increases the cost. β-glucosidases with improved activity and thermostability are therefore of great commercial interest. The fungus Trichoderma reseei expresses thermostable cellulolytic enzymes which have been widely studied as attractive targets for industrial applications. Genetically modified β-glucosidases from Trichoderma reseei have been recently commercialised. We have developed an approach in which screening of low molecular weight molecules (fragments) identifies compounds that increase enzyme activity and are currently characterizing fragment-based activators of TrBgl2. A structural analysis of the 55 kDa apo form of TrBgl2 revealed a classical (α/β)

Indexed as

Carbon-13 Magnetic Resonance SpectroscopyProton Magnetic Resonance Spectroscopybeta-GlucosidaseFungal ProteinsHypocrealesNitrogen IsotopesProtein Structure, Secondarybeta-GlucosidaseFungal ProteinsNitrogen-15Nitrogen IsotopesEnzyme activatorsResonance assignmentTrBgl2β-glucosidase

Identifiers

PMID32562251
PMCPMC7462900
OpenAlexW3036883665

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.