Evidence map›Paper›PMID 32562236›Full record

ArticleMolecular neurobiology2020

Adipose-Derived Mesenchymal Stem Cells and Conditioned Medium Attenuate the Memory Retrieval Impairment During Sepsis in Rats.

Fariba Akhondzadeh, Mehri Kadkhodaee, Behjat Seifi, Ghorbangol Ashabi, Farzaneh Kianian, Kamal Abdolmohammadi, Maryam Izad, Maryam Adelipour, Mina Ranjbaran

Abstract read
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In one paragraph

Article in Molecular neurobiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 21 citations in OpenAlex.

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  13. Infectious disease-associated encephalopathies.Critical care (London, England) · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Fariba AkhondzadehDepartment of Physiology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, 1417613151, Iran.
Mehri KadkhodaeeDepartment of Physiology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, 1417613151, Iran.
Behjat SeifiDepartment of Physiology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, 1417613151, Iran.
Ghorbangol AshabiDepartment of Physiology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, 1417613151, Iran.
Farzaneh KianianDepartment of Physiology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, 1417613151, Iran.
Kamal AbdolmohammadiDepartment of Immunology, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran.
Maryam IzadDepartment of Immunology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Maryam AdelipourDepartment of Clinical Biochemistry, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Mina RanjbaranDepartment of Physiology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, 1417613151, Iran. m-ranjbaran@tums.ac.ir.ORCID http://orcid.org/0000-0003-4791-8911
Tehran University of Medical Sciences · IRAhvaz Jundishapur University of Medical Sciences · IRKurdistan University of Medical Sciences · IR

Funding

Tehran University of Medical Sciences 41504
6 · The paper itself

Abstract

In this study, we hypothesized that sepsis induction impairs memory retrieval in rats while transplanted mesenchymal stem cells (MSCs) and MSC-conditioned medium (MSC-CM) application are capable of attenuating those complications. MSCs were obtained from adipose tissue of rats and at the second culture passage; MSCs and MSC-CM were collected. Rats were randomly divided into four experimental groups: sham, CLP, MSC, and MSC-CM. Sepsis was induced by cecal ligation and puncture (CLP) model in the CLP, MSC, and MSC-CM groups. The MSC group received 1 × 10

Indexed as

Animalsbcl-2-Associated X ProteinBlood PressureCalcium-Calmodulin-Dependent Protein Kinase Type 2Caspase 3CecumCulture Media, ConditionedDisease Models, AnimalHippocampusLigationMaleMemory DisordersMental RecallMesenchymal Stem CellsMesenchymal Stem Cell TransplantationOpen Field Testbcl-2-Associated X ProteinCalcium-Calmodulin-Dependent Protein Kinase Type 2Caspase 3Culture Media, ConditionedProto-Oncogene Proteins c-fosCAMKIIC-fos proteinsConditioned mediumHippocampusMemoryMesenchymal stem cellsSepsis

Identifiers

PMID32562236
OpenAlexW3036360682

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.