Evidence map›Paper›PMID 32562172›Full record

ArticleSleep & breathing = Schlaf & Atmung2021

The dorsal and the ventral side of hypoglossal motor nucleus showed different response to chronic intermittent hypoxia in rats.

Rui Cao, Min-Juan Zhang, Yun-Tao Zhou, Ya-Jie Liu, Huan-Huan Wang, Qin-Xin Zhang, Ya-Wen Shi, Jia-Chen Li, Thian-Sze Wong, Min Yin

Abstract read
PubMed Publisher
In one paragraph

Article in Sleep & breathing = Schlaf & Atmung, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Rui CaoDepartment of Otorhinolaryngology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
Min-Juan ZhangDepartment of Otorhinolaryngology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
Yun-Tao ZhouExperimental Teaching Demonstration Centre, School of Rehabilitation Medicine, Nanjing Medical University, Nanjing, China.
Ya-Jie LiuDepartment of Otorhinolaryngology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
Huan-Huan WangDepartment of Otorhinolaryngology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
Qin-Xin ZhangDepartment of Otorhinolaryngology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
Ya-Wen ShiDepartment of Otorhinolaryngology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
Jia-Chen LiDepartment of Otorhinolaryngology, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China.
Thian-Sze WongDivision of Head and Neck, the department of surgery, the faculty of medicine, The University of Hong Kong, Hong Kong, China.
Min YinDepartment of Otorhinolaryngology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China. simisodo@126.com.ORCID http://orcid.org/0000-0002-6297-0016
Jiangsu Province Hospital · CNNanjing Medical University · CNSoochow University · CNUniversity of Hong Kong · HK

Funding

Jiangsu Provincial Commission of Health and Family Planning LGY2017070Nanjing Medical University NMUB2019025
6 · The paper itself

Abstract

purposeTo study neurochemical reactions to chronic intermittent hypoxia (CIH) in the hypoglossal nucleus (HN) of rats.

methodsAdult male Sprague-Dawley rats (n = 12) were randomly divided into two groups (the CIH and the control group). The CIH rats were housed in a hypoxic chamber with the fraction of oxygen volume alternating between 21% and 5% by providing air for 60 s and then providing nitrogen for 60 s from 8:30 am to 16:30 pm each day for 35 days. The control group was housed in a cabin with normal oxygen levels. We studied the expression of c-fos protein, 5-hydroxytryptamine (5-HT) positive terminals, and its 2A receptors in hypoglossal nuclei by immunohistochemistry.

resultsThe expression of c-fos, 5-HT positive terminals, and accordingly 5-HT 2A receptors in the CIH group were significantly higher than that in the controls (p < 0.05). The ventral side of the HN showed a clearly higher expression of 5-HT and its 2A receptors than the dorsal side (p < 0.05).

conclusionThere were 2 responses of the HN to CIH. First, CIH induced a higher expression of 5-HT positive terminals and its 2A receptors, and second, this reaction was much more evident in ventral side than in the dorsal side. We postulate that these responses may serve to be a protective and compensatory mechanism for CIH.

Indexed as

AnimalsDisease Models, AnimalHypoglossal NerveHypoxiaImmunohistochemistryMaleMedulla OblongataProto-Oncogene Proteins c-fosRandom AllocationRatsRats, Sprague-DawleyReceptor, Serotonin, 5-HT2ASerotoninProto-Oncogene Proteins c-fosReceptor, Serotonin, 5-HT2ASerotonin5-HT5-HT 2AChronic intermittent hypoxiaSleep apnea

Identifiers

PMID32562172
OpenAlexW3036985869

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.