Evidence map›Paper›PMID 32562095›Full record

ReviewJournal of assisted reproduction and genetics2020

ART strategies in Klinefelter syndrome.

Wei Chen, Ming Zhu Bai, Yixia Yang, Di Sun, Sufang Wu, Jian Sun, Yu Wu, Youji Feng, Youheng Wei, Zijiang Chen and 1 more

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of assisted reproduction and genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Wei ChenReproductive Medicine Center, Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiaotong University, Shanghai, 200080, China.
Ming Zhu BaiReproductive Medicine Center, Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiaotong University, Shanghai, 200080, China.ORCID http://orcid.org/0000-0001-6210-4890
Yixia YangReproductive Medicine Center, Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiaotong University, Shanghai, 200080, China.
Di SunReproductive Medicine Center, Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiaotong University, Shanghai, 200080, China.
Sufang WuReproductive Medicine Center, Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiaotong University, Shanghai, 200080, China.
Jian SunReproductive Medicine Center, Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiaotong University, Shanghai, 200080, China.
Yu WuReproductive Medicine Center, Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiaotong University, Shanghai, 200080, China.
Youji FengReproductive Medicine Center, Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiaotong University, Shanghai, 200080, China.
Youheng WeiInstitute of Bioscience and Biotechnology, Yangzhou University, Yangzhou, 225009, China.
Zijiang ChenDepartment of Obstetrics and Gynecology, Center for Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, 250021, China.
Zhenbo ZhangReproductive Medicine Center, Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiaotong University, Shanghai, 200080, China. zhangzhenbozzb@shsmu.edu.cn.
Shanghai First People's Hospital · CNShandong University · CNShanghai Chest Hospital · CNYangzhou University · CN

Funding

National Natural Science Foundation of China 81370074National Natural Science Foundation of China 81672562National Natural Science Foundation of China 81872111National Natural Science Foundation of China 81902630Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant Support 20181714Shanghai Municipal Science and Technology Committee of Shanghai outstanding academic leaders plan 19XD1423100the cross project of Medical and Engineering YG2016MS27the projects sponsored by the development fund for Shanghai talents, the Shanghai Municipal Public Health Bureau XYQ2013119
6 · The paper itself

Abstract

purposePatients with Klinefelter syndrome (KS) who receive assisted reproductive technology (ART) treatment often experience poor pregnancy rates due to decreased fertilization, cleavage, and implantation rates and even an increased miscarriage rate. Mounting evidence from recent studies has shown that various technological advances and approaches could facilitate the success of ART treatment for KS patients. In this review, we summarize the methods for guiding KS patients during ART and for developing optimal strategies for preserving fertility, improving pregnancy rate and live birth rate, and avoiding the birth of KS infants.

methodsWe searched PubMed and Google Scholar publications related to KS patients on topics of controlled ovarian stimulation protocols, sperm extraction, fertility preservation, gamete artificial activation, round spermatid injection (ROSI), and non-invasive prenatal screening (PGD) methods.

resultsThis review outlines the different ovulation-inducing treatments for female partners according to the individual sperm status in the KS patient. We further summarize the methods of retrieving sperm, storing, and freezing rare sperm. We reviewed different methods of gamete artificial activation and discussed the feasibility of ROSI for sterile KS patients who absolutely lack sperm. The activation of eggs in the process of intracytoplasmic sperm injection and non-invasive PGD are urgently needed to prevent the birth of KS infants.

conclusionThe integrated strategies will pave the way for the establishment of ART treatment approaches and improve the clinical outcome for KS patients.

Indexed as

Birth RateEmbryo ImplantationFemaleFertility PreservationHumansKlinefelter SyndromeMalePregnancyPregnancy RateReproductive Techniques, AssistedSperm Injections, IntracytoplasmicAdministration strategyFertility preservationKlinefelter syndromeSingle sperm cryopreservationTESE

Identifiers

PMID32562095
PMCPMC7492331
OpenAlexW3035811126

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.