Evidence map›Paper›PMID 32562092›Full record

ReviewCurrent rheumatology reports2020

Is There a Brain/Heart Interaction in Rheumatoid Arthritis and Seronegative Spondyloartropathies? A Combined Brain/Heart Magnetic Resonance Imaging Reveals the Answer.

George Markousis-Mavrogenis, Loukia Koutsogeorgopoulou, Theodoros Dimitroulas, Gikas Katsifis, Vasiliki Vartela, Dimos Mitsikostas, Genovefa Kolovou, Paraskevi Voulgari, Petros P Sfikakis, George D Kitas and 1 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current rheumatology reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 2 countries.

George Markousis-MavrogenisOnassis Cardiac Surgery Center, 50 Esperou Street, 175-61 P.Faliro, Athens, Greece.
Loukia KoutsogeorgopoulouDepartment of Pathophysiology, Laikon Hospital, Athens, Greece.
Theodoros DimitroulasFourth Department of Internal Medicine, School of Medicine, Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Gikas KatsifisNaval Hospital, Athens, Greece.
Vasiliki VartelaOnassis Cardiac Surgery Center, 50 Esperou Street, 175-61 P.Faliro, Athens, Greece.
Dimos MitsikostasAretaiion Hospital, Athens, Greece.
Genovefa KolovouOnassis Cardiac Surgery Center, 50 Esperou Street, 175-61 P.Faliro, Athens, Greece.
Paraskevi VoulgariRheumatology Clinic, University of Ioannina, Ioannina, Greece.
Petros P SfikakisKapodistrian University of Athens, Athens, Greece.
George D KitasArthritis Research UK Epidemiology Unit, Manchester University, Manchester, UK.
Sophie I MavrogeniOnassis Cardiac Surgery Center, 50 Esperou Street, 175-61 P.Faliro, Athens, Greece. soma13@otenet.gr.ORCID 0000-0003-1089-7766
National and Kapodistrian University of Athens · GROnassis Cardiac Surgery Center · GRAristotle University of Thessaloniki · GRAthens Naval & Veterans Hospital · GRLaiko General Hospital of Athens · GRUniversity of Ioannina · GRUniversity of Manchester · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewTo present the interaction between brain/heart and emphasize the role of combined brain/heart magnetic resonance imaging (MRI) in patients with rheumatoid arthritis (RA) and other seronegative spondyloarthropathies (SNA). RECENT

findingsBoth traditional cardiovascular disease (CVD) risk factors and intrinsic RA/SNA features contribute to the increased CVD-related morbidity/mortality. CVD in RA usually occurs a decade earlier than age- and sex-matched controls, and RA patients are twice more likely to develop myocardial infarction irrespective of age, history of prior CVD, and traditional CVD risk factors. RA also increases risk of non-ischemic heart failure (HF), valvular disease, and myo-pericarditis. CVD in SNA affects more commonly patients with long-standing disease. Ascending aortitis, aortic/mitral insufficiency, conduction defects, and diastolic dysfunction are the commonest findings in ankylosing spondylitis (AS). CVD is also the leading cause of death in psoriatic arthritis (PsA), due to myopericarditis, diastolic dysfunction, and valvular disease. Brain damage, due to either ischemic or hemorrhagic stroke and silent vascular damage, such as white matter hyperenhancement (WMH), is increased in both RA/SNA and may lead to cognitive dysfunction, depression, and brain atrophy. Magnetic resonance imaging (MRI) is ideal for serial brain/heart evaluation of patients with systemic diseases. RA/SNA patients are at high risk for brain/heart damage at early age, irrespectively of classic risk factors. Until more data will be obtained, a combined brain/heart MRI evaluation can be proposed in RA/SNA with new onset of arrhythmia and/or HF, cognitive dysfunction and/or depression.

Indexed as

Arthritis, RheumatoidBrainCardiovascular DiseasesHeartArthritis, PsoriaticHumansMagnetic Resonance ImagingRisk FactorsArrhythmiaBrain lesionsBrain magnetic resonance imagingCardiovascular diseaseCardiovascular magnetic resonance imagingCognitive dysfunctionDepressionHeart failureNeuro-psychiatric symptomsRheumatoid arthritisSeronegative arthropathies

Identifiers

PMID32562092
OpenAlexW3036827642

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.