ArticleWorld journal of microbiology & biotechnology2020
A transcriptome analysis of the antibacterial mechanism of flavonoids from Sedum aizoon L. against Shewanella putrefaciens.
Article in World journal of microbiology & biotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 58 citations in OpenAlex.
- Synergistic chemodynamic-photothermal therapy of super-resistant Enterobacter asburiae-infected sepsis using multifunctional mesoporous nanocomposite.Journal of nanobiotechnology · 2026Article
- Research Progress on the Antibacterial Activity of Natural Flavonoids.Antibiotics (Basel, Switzerland) · 2025Review
- Research Progress Regarding PsychrotrophicFoods (Basel, Switzerland) · 2025Review
- Phytochemical Characterization and Bioactivity Evaluation of Extracts Obtained via Ultrasound-Assisted Extraction of Medicinal PlantPlants (Basel, Switzerland) · 2024Article
- Review
- Proteomics reveals energy limitation and amino acid consumption as antibacterial mechanism of linalool againstFood chemistry: X · 2023Article
- Anthocyanins fromFrontiers in microbiology · 2023Article
- To explore the active constituents ofAnnals of translational medicine · 2022Article
- Flavonoids from Sedum aizoon L. inhibit Botrytis cinerea by negatively affecting cell membrane lipid metabolism.Applied microbiology and biotechnology · 2022Article
- The regulatory effect of total flavonoids ofCurrent research in food science · 2022Article
- Antibacterial activity and mechanism of flavonoids fromFrontiers in microbiology · 2022Article
- Anti-fungal Activity ofFrontiers in plant science · 2022Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Flavonoids from Sedum aizoon L. (FSAL) possess prominent antibacterial activity against Shewanella putrefaciens isolated from sea food. In the current study, the involved molecular mechanisms were investigated using transcriptome analyses combined with bioinformatics analysis in vitro for the first time. Results showed that treatment of FSAL (1.0 MIC) damaged the permeability and integrity of cell membrane and induced 721 differentially expressed genes (DEGs) in tested bacteria at transcriptional levels, including 107 DEGs were up-regulated and 614 DEGs were down-regulated. In addition, the RNA-Seq analysis revealed that the majority of DEGs mainly involved in pathways of lipopolysaccharide biosynthesis, glycerophospholipid metabolism, biosynthesis of amino acids, purine metabolism, ABC transporters and response to stimulus. In summary, the integrated results indicated that the intervention of FSAL induced destruction of cell wall and membrane, disorder of the metabolic process and redox balance, and damage of nucleic acids in S. putrefaciens, at last resulted in the death of cells. This study provided new insights into the anti- S. putrefaciens molecular mechanism underlying the treatment of FSAL, which may be served as the basis guide for identifying potential antimicrobial targets and application of FSAL in food safety.
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Registered trials
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