Evidence map›Paper›PMID 32561881›Full record

ArticleScientific reports2020

Selective, high-contrast detection of syngeneic glioblastoma in vivo.

Richard B Banati, Paul Wilcox, Ran Xu, Grace Yin, Emily Si, Eric Taeyoung Son, Mauricio Shimizu, R M Damian Holsinger, Arvind Parmar, David Zahra and 5 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Longitudinal [Biomedicines · 2022
    Article
  5. Article
  6. Imaging of the glioma microenvironment by TSPO PET.European journal of nuclear medicine and molecular imaging · 2021
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Richard B BanatiAustralian Nuclear Science and Technology Organization, Locked Bag 2001, Kirrawee DC, NSW, 2232, Australia. richard.banati@sydney.edu.au.
Paul WilcoxBrain Tumour Research, Brain and Mind Centre, Faculty of Medicine and Health, The University of Sydney, 94 Mallett Street, Camperdown, NSW, 2050, Australia.
Ran XuBrain Tumour Research, Brain and Mind Centre, Faculty of Medicine and Health, The University of Sydney, 94 Mallett Street, Camperdown, NSW, 2050, Australia.
Grace YinBrain Tumour Research, Brain and Mind Centre, Faculty of Medicine and Health, The University of Sydney, 94 Mallett Street, Camperdown, NSW, 2050, Australia.
Emily SiBrain Tumour Research, Brain and Mind Centre, Faculty of Medicine and Health, The University of Sydney, 94 Mallett Street, Camperdown, NSW, 2050, Australia.
Eric Taeyoung SonBrain Tumour Research, Brain and Mind Centre, Faculty of Medicine and Health, The University of Sydney, 94 Mallett Street, Camperdown, NSW, 2050, Australia.
Mauricio ShimizuBrain Tumour Research, Brain and Mind Centre, Faculty of Medicine and Health, The University of Sydney, 94 Mallett Street, Camperdown, NSW, 2050, Australia.
R M Damian HolsingerMolecular Neuroscience, Brain and Mind Centre, Faculty of Medicine and Health, The University of Sydney, 94 Mallett Street, Camperdown, NSW, 2050, Australia.
Arvind ParmarAustralian Nuclear Science and Technology Organization, Locked Bag 2001, Kirrawee DC, NSW, 2232, Australia.
David ZahraAustralian Nuclear Science and Technology Organization, Locked Bag 2001, Kirrawee DC, NSW, 2232, Australia.
Andrew ArthurAustralian Nuclear Science and Technology Organization, Locked Bag 2001, Kirrawee DC, NSW, 2232, Australia.
Ryan J MiddletonAustralian Nuclear Science and Technology Organization, Locked Bag 2001, Kirrawee DC, NSW, 2232, Australia.
Guo-Jun LiuAustralian Nuclear Science and Technology Organization, Locked Bag 2001, Kirrawee DC, NSW, 2232, Australia.
Arnaud CharilAustralian Nuclear Science and Technology Organization, Locked Bag 2001, Kirrawee DC, NSW, 2232, Australia.
Manuel B GraeberBrain Tumour Research, Brain and Mind Centre, Faculty of Medicine and Health, The University of Sydney, 94 Mallett Street, Camperdown, NSW, 2050, Australia. manuel@graeber.net.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glioblastoma is a highly malignant, largely therapy-resistant brain tumour. Deep infiltration of brain tissue by neoplastic cells represents the key problem of diffuse glioma. Much current research focuses on the molecular makeup of the visible tumour mass rather than the cellular interactions in the surrounding brain tissue infiltrated by the invasive glioma cells that cause the tumour's ultimately lethal outcome. Diagnostic neuroimaging that enables the direct in vivo observation of the tumour infiltration zone and the local host tissue responses at a preclinical stage are important for the development of more effective glioma treatments. Here, we report an animal model that allows high-contrast imaging of wild-type glioma cells by positron emission tomography (PET) using [18 F]PBR111, a selective radioligand for the mitochondrial 18 kDa Translocator Protein (TSPO), in the Tspo

Identifiers

PMID32561881
PMCPMC7305160

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.