ArticleHeredity2020
An alternative route of bacterial infection associated with a novel resistance locus in the Daphnia-Pasteuria host-parasite system.
Article in Heredity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- Article
- Genetic basis of resistance in hosts facing alternative infection strategies by a virulent bacterial pathogen.G3 (Bethesda, Md.) · 2025Article
- Inference of Host-Pathogen Interaction Matrices from Genome-Wide Polymorphism Data.Molecular biology and evolution · 2024Article
- Long-term balancing selection for pathogen resistance maintains trans-species polymorphisms in a planktonic crustacean.Nature communications · 2024Article
- Ectopical expression of bacterial collagen-like protein supports its role as adhesin in host-parasite coevolution.Royal Society open science · 2024Article
- Uncovering the Genomic Basis of Infection Through Co-genomic Sequencing of Hosts and Parasites.Molecular biology and evolution · 2023Article
- Out of the 'host' box: extreme off-host conditions alter the infectivity and virulence of a parasitic bacterium.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Article
- QTL study reveals candidate genes underlying host resistance in a Red Queen model system.PLoS genetics · 2023Article
- Genetic slippage after sex maintains diversity for parasite resistance in a natural host population.Science advances · 2022Article
- Review
- Population-Genomic Analysis Identifies a Low Rate of Global Adaptive Fixation in the Proteins of the Cyclical Parthenogen Daphnia magna.Molecular biology and evolution · 2022Article
- Balancing Selection for Pathogen Resistance Reveals an Intercontinental Signature of Red Queen Coevolution.Molecular biology and evolution · 2021Article
- Infection phenotypes of a coevolving parasite are highly diverse, structured, and specific.Evolution; international journal of organic evolution · 2021Article
- A Two-Locus System with Strong Epistasis Underlies Rapid Parasite-Mediated Evolution of Host Resistance.Molecular biology and evolution · 2021Article
- Genome-Wide Association Analysis Identifies a Genetic Basis of Infectivity in a Model Bacterial Pathogen.Molecular biology and evolution · 2020Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To understand the mechanisms of antagonistic coevolution, it is crucial to identify the genetics of parasite resistance. In the Daphnia magna-Pasteuria ramosa host-parasite system, the most important step of the infection process is the one in which P. ramosa spores attach to the host's foregut. A matching-allele model (MAM) describes the host-parasite genetic interactions underlying attachment success. Here we describe a new P. ramosa genotype, P15, which, unlike previously studied genotypes, attaches to the host's hindgut, not to its foregut. Host resistance to P15 attachment shows great diversity across natural populations. In contrast to P. ramosa genotypes that use foregut attachment, P15 shows some quantitative variation in attachment success and does not always lead to successful infections, suggesting that hindgut attachment represents a less-efficient infection mechanism than foregut attachment. Using a Quantitative Trait Locus (QTL) approach, we detect two significant QTLs in the host genome: one that co-localizes with the previously described D. magna PR locus of resistance to foregut attachment, and a second, major QTL located in an unlinked genomic region. We find no evidence of epistasis. Fine mapping reveals a genomic region, the D locus, of ~13 kb. The discovery of a second P. ramosa attachment site and of a novel host-resistance locus increases the complexity of this system, with implications for both for the coevolutionary dynamics (e.g., Red Queen and the role of recombination), and for the evolution and epidemiology of the infection process.
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