ArticleNature communications2020
A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction.
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Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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57citing papers in PubMed
5.7field-weighted citation impact, top 3% of its field
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Who cites it
57 citing papers in PubMed, 93 citations in OpenAlex.
- Autoinhibitory control of MLKL governs pseudokinase domain phosphorylation and oligomerization during necroptosis.Cell reports · 2026Article
- Necroptosis in both tumour and stromal compartments determines responsiveness to immunogenic cell death-based immunotherapy.Nature communications · 2026Article
- Necroptotic cell death consequences and disease relevance.Nature immunology · 2025Review
- Disrupting membranes, controlling cell fate: the role of pore-forming proteins in cell death and therapy.Apoptosis : an international journal on programmed cell death · 2025Review
- Identification of high-risk non-synonymous SNPs (nsSNPs) in DNAH1 and DNAH17 genes associated with male infertility: a bioinformatics analysis.Journal of applied genetics · 2025Article
- Exploring the effects of missense mutations on protein thermodynamics through structure-based approaches: findings from the CAGI6 challenges.Human genetics · 2025Article
- For Better or Worse: The Impact of Necrotic Cell Death Modalities.Advances in experimental medicine and biology · 2025Review
- The Evolution and Biological Activity of Metazoan Mixed Lineage Kinase Domain-Like Protein (MLKL).International journal of molecular sciences · 2024Article
- Inhibitors identify an auxiliary role for mTOR signalling in necroptosis execution downstream of MLKL activation.The Biochemical journal · 2024Article
- An immunohistochemical atlas of necroptotic pathway expression.EMBO molecular medicine · 2024Article
- Hyperlipidemia-induced hematopoiesis is repressed by MLKL in endothelial cells of the splenic niche.Nature cardiovascular research · 2024Article
- Immunogenic cell death in cancer: targeting necroptosis to induce antitumour immunity.Nature reviews. Cancer · 2024Review
- Pervasive loss of regulated necrotic cell death genes in elephants, hyraxes, and sea cows (bioRxiv : the preprint server for biology · 2024Article
- Characterizing and predicting ccRCC-causing missense mutations in Von Hippel-Lindau disease.Human molecular genetics · 2024Article
- Necroptosis and Its Involvement in Various Diseases.Advances in experimental medicine and biology · 2024Article
- AI-Driven Enhancements in Drug Screening and Optimization.Methods in molecular biology (Clifton, N.J.) · 2024Article
- THPLM: a sequence-based deep learning framework for protein stability changes prediction upon point variations using pretrained protein language model.Bioinformatics (Oxford, England) · 2023Article
- Phosphorylation-dependent pseudokinase domain dimerization drives full-length MLKL oligomerization.Nature communications · 2023Article
- A common human MLKL polymorphism confers resistance to negative regulation by phosphorylation.Nature communications · 2023Article
- Skp2-mediated MLKL degradation confers cisplatin-resistant in non-small cell lung cancer cells.Communications biology · 2023Article
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Authors and funding
70 authors at 20 institutions in 8 countries.
Joanne M Hildebrand *The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia. jhildebrand@wehi.edu.au.ORCID http://orcid.org/0000-0002-1456-2042
Maria Kauppi *The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
Ian J MajewskiThe Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
Zikou LiuThe Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.ORCID http://orcid.org/0000-0002-0787-5083
Allison J CoxStead Family Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, IA, 52242, USA.
Sanae MiyakeDepartment of Biochemistry, Toho University School of Medicine, Ota-ku, Tokyo, 143-8540, Japan.
Emma J PetrieThe Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
Michael A SilkDepartment of Biochemistry and Molecular Biology, Bio21 Institute, University of Melbourne, Melbourne, VIC, 3052, Australia.
Zhixiu LiTranslational Genomics Group, Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Queensland University of Technology (QUT) at Translational Research Institute, Brisbane, Australia.
Maria C TanzerThe Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
Gabriela BrumattiThe Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
Samuel N YoungThe Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
Cathrine HallThe Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
Sarah E GarnishThe Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
Jason CorbinThe Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
Michael D StutzThe Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.ORCID http://orcid.org/0000-0002-9298-1728
Ladina Di RagoThe Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
Pradnya GangatirkarThe Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
Emma C JosefssonThe Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.ORCID http://orcid.org/0000-0001-6478-5204
Kristin RigbyeThe Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
Holly AndertonThe Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.ORCID http://orcid.org/0000-0003-3913-9686
James A RickardThe Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
Anne TripaydonisThe Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
Julie SheridanThe Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.ORCID http://orcid.org/0000-0002-1478-3662
Thomas S ScerriThe Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.ORCID http://orcid.org/0000-0003-0992-4042
Victoria E JacksonThe Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
Peter E CzabotarThe Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.ORCID http://orcid.org/0000-0002-2594-496X
Jian-Guo ZhangThe Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
Leila VargheseThe Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.ORCID http://orcid.org/0000-0003-2476-0306
Cody C AllisonThe Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
Marc PellegriniThe Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
Gillian M TannahillThe Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
Esme C HatchellThe Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
Tracy A WillsonThe Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
Dina StockwellThe Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
Carolyn A de GraafThe Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.ORCID http://orcid.org/0000-0001-8380-5311
Janelle CollingeThe Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
Adrienne HiltonThe Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
Natasha SilkeThe Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
Sukhdeep K SpallThe Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
Diep ChauThe Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
Vicki AthanasopoulosDepartment of Immunology and Infectious Disease and Centre for Personalised Immunology (NHMRC Centre for Research Excellence), John Curtin School of Medical Research, Australian National University, Canberra, Australia.
Donald MetcalfThe Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
Ronald M LaxerDivision of Rheumatology, The Hospital for Sick Children and the University of Toronto, Toronto, ON, Canada.
Alexander G BassukStead Family Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, IA, 52242, USA.ORCID http://orcid.org/0000-0002-4067-2157
Benjamin W DarbroStead Family Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, IA, 52242, USA.
Maria A Fiatarone SinghFaculty of Health Sciences and Sydney Medical School, University of Sydney, Sydney, Australia.
Nicole VlahovichDepartment of Sports Medicine, Australian Institute of Sport, Bruce, ACT, Australia.
David HughesDepartment of Sports Medicine, Australian Institute of Sport, Bruce, ACT, Australia.
Maria KozlovskaiaDepartment of Sports Medicine, Australian Institute of Sport, Bruce, ACT, Australia.
David B AscherDepartment of Biochemistry and Molecular Biology, Bio21 Institute, University of Melbourne, Melbourne, VIC, 3052, Australia.ORCID http://orcid.org/0000-0003-2948-2413
Klaus WarnatzDepartment of Internal Medicine, Clinic for Rheumatology and Clinical Immunology, Medical Center -University of Freiburg, Faculty of Medicine, Freiburg, 79106, Germany.
Nils VenhoffDepartment of Internal Medicine, Clinic for Rheumatology and Clinical Immunology, Medical Center -University of Freiburg, Faculty of Medicine, Freiburg, 79106, Germany.
Jens ThielDepartment of Internal Medicine, Clinic for Rheumatology and Clinical Immunology, Medical Center -University of Freiburg, Faculty of Medicine, Freiburg, 79106, Germany.
Christine BibenThe Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.ORCID http://orcid.org/0000-0003-4387-8676
Stefan BlumPrincess Alexandra Hospital, Brisbane, QLD, Australia.
John ReveilleMemorial Hermann Texas Medical Centre, Houston, TX, USA.
Michael S HildebrandEpilepsy Research Centre, Department of Medicine, University of Melbourne, Austin Health, Heidelberg, VIC, 3084, Australia.
Carola G VinuesaDepartment of Immunology and Infectious Disease and Centre for Personalised Immunology (NHMRC Centre for Research Excellence), John Curtin School of Medical Research, Australian National University, Canberra, Australia.
Pamela McCombeThe University of Queensland, UQ Centre for Clinical Research, Royal Brisbane & Women's Hospital, Brisbane, Australia.ORCID http://orcid.org/0000-0003-2704-8517
Matthew A BrownTranslational Genomics Group, Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Queensland University of Technology (QUT) at Translational Research Institute, Brisbane, Australia.ORCID http://orcid.org/0000-0003-0538-8211
Benjamin T KileThe Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.ORCID http://orcid.org/0000-0002-8836-8947
Catriona McLeanDepartment of Anatomical Pathology, The Alfred Hospital, Prahran, VIC, 3181, Australia.ORCID http://orcid.org/0000-0002-0302-5727
Melanie BahloThe Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.ORCID http://orcid.org/0000-0001-5132-0774
Seth L MastersThe Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.ORCID http://orcid.org/0000-0003-4763-576X
Hiroyasu NakanoDepartment of Biochemistry, Toho University School of Medicine, Ota-ku, Tokyo, 143-8540, Japan.ORCID http://orcid.org/0000-0003-4843-1427
Polly J FergusonStead Family Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, IA, 52242, USA.
James M MurphyThe Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.ORCID http://orcid.org/0000-0003-0195-3949
Warren S AlexanderThe Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia. alexandw@wehi.edu.au.
John SilkeThe Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia. silke@wehi.edu.au.ORCID http://orcid.org/0000-0002-7611-5774
The University of Melbourne · AUUniversity of Iowa · USUniversity of Freiburg · DEAustralian National University · AUBaker Heart and Diabetes Institute · AUSports Medicine Australia · AUThe Royal Melbourne Hospital · AUToho University · JPTranslational Research Institute · AUCSL (United Kingdom) · GBMemorial Hermann–Texas Medical Center · USOregon Health & Science University · USPrincess Alexandra Hospital · AURoyal Children's Hospital · AUThe Alfred Hospital · AUThe University of Queensland · AUThe University of Sydney · AUUniversity of Canberra · AUUniversity of Toronto · CAWalter and Eliza Hall Institute of Medical Research · AU
Funding
PREDOCTORAL TRAINING PROGRAM IN GENETICST32GM008629 · NIGMS · UNIVERSITY OF IOWA · PI EBERL, DANIEL F · 1997 to 2021
$4.1MGenetic & immunologic etiology of chronic recurrent multifocal osteomyelitis-CRMOR01AR059703 · NIAMS · UNIVERSITY OF IOWA · PI BASSUK, ALEXANDER G, FERGUSON, POLLY J · 2010 to 2019
$3.5MBioinformatics Training in the Life Sciences and BiomedicineT32GM082729 · NIGMS · UNIVERSITY OF IOWA · PI CASAVANT, THOMAS L. · 2009 to 2013
$544kArthritis Research UK 18797Arthritis Research UK 19536NIAMS NIH HHS R01 AR059703NIGMS NIH HHS T32 GM008629NIGMS NIH HHS T32 GM082729Wellcome Trust 076113Wellcome Trust 208694/Z/17/Z
Abstract
MLKL is the essential effector of necroptosis, a form of programmed lytic cell death. We have isolated a mouse strain with a single missense mutation, Mlkl
Indexed as
AnimalsAnimals, NewbornHematopoietic Stem CellsHematopoietic SystemHereditary Autoinflammatory DiseasesHumansInflammationMiceMutation, MissenseNecroptosisOsteomyelitisProtein KinasesMLKL protein, humanMLKL protein, mouseProtein Kinases
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