ArticleNature communications2020
Eliminating the capsule-like layer to promote glucose uptake for hyaluronan production by engineered Corynebacterium glutamicum.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 124 citations in OpenAlex.
- Developing Metal-Polyphenol Network-Based Single-Protein Particle Encapsulation System for Sustained Release of Whey Protein to Mitigate Sarcopenia.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Condensate-based sequestration enables high-efficiency synthesis of mussel foot protein Mcofp-3.Applied and environmental microbiology · 2026Article
- EngineeringBiomolecules · 2026Article
- Tailored molecular weight hyaluronic acid production by engineered Lactococcus lactis.Microbial cell factories · 2026Article
- Synthetic biology for heparin biomanufacturing.Bioresources and bioprocessing · 2026Review
- Molecular weight regulation strategies in microbial synthesis of hyaluronic acid: current status and future perspectives.World journal of microbiology & biotechnology · 2025Review
- Review of the role of submucosal injection materials in digestive endoscopy.Annals of medicine · 2025Review
- Design of orthogonal and portable RNA devices for post-transcriptional regulation by reverse engineering type I toxin-antitoxin systems.Nucleic acids research · 2025Article
- Coupling optimization of cell growth cycle and key enzyme membrane localization for enhanced synthesis of high molecular weight heparosan by Corynebacterium glutamicum.Bioresources and bioprocessing · 2025Article
- CRISPRi-assisted metabolic engineering of cyanobacteria for photosynthetic hyaluronic acid from COJournal of biological engineering · 2025Article
- Metabolic engineering of Escherichia coli for enhanced production of hyaluronic acid.Biotechnology letters · 2025Article
- Regulating cellular metabolism and morphology to achieve high-yield synthesis of hyaluronan with controllable molecular weights.Nature communications · 2025Article
- Hyaluronidases improve the hyaluronic acid yield during the fermentation ofFrontiers in bioengineering and biotechnology · 2025Article
- Engineering artificial cross-species promoters with different transcriptional strengths.Synthetic and systems biotechnology · 2025Article
- Effect ofFoods (Basel, Switzerland) · 2024Article
- Biosynthesis of Apigenin Glucosides in EngineeredJournal of microbiology and biotechnology · 2024Article
- Review
- Insulin Conformation Changes in Hybrid Alginate-Gelatin Hydrogel Particles.Molecules (Basel, Switzerland) · 2024Article
- Reprogramming Metabolic Flux in Escherichia Coli to Enhance Chondroitin Production.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Microbial Cell Factories in the Bioeconomy Era: From Discovery to Creation.Biodesign research · 2024Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hyaluronan is widely used in cosmetics and pharmaceutics. Development of robust and safe cell factories and cultivation approaches to efficiently produce hyaluronan is of many interests. Here, we describe the metabolic engineering of Corynebacterium glutamicum and application of a fermentation strategy to manufacture hyaluronan with different molecular weights. C. glutamicum is engineered by combinatorial overexpression of type I hyaluronan synthase, enzymes of intermediate metabolic pathways and attenuation of extracellular polysaccharide biosynthesis. The engineered strain produces 34.2 g L
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Registered trials
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