Evidence map›Paper›PMID 32561648›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Jie Tan, Rengyun Liu, Guangwu Zhu, Christopher B Umbricht, Mingzhao Xing

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 44 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. BRAFThyroid research · 2025
    Article
  7. Blocking interplay between TERT and c-Myc: a new therapeutic strategy forInternational journal of biological sciences · 2025
    Article
  8. Article
  9. Treatment of UnresectableJCEM case reports · 2024
    Article
  10. Review
  11. Review
  12. Heliyon · 2023
    Article
  13. Article
  14. Article
  15. Papillary thyroid cancer organoids harboring BRAFJournal of translational medicine · 2023
    Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 2 countries.

Jie TanLaboratory for Cellular and Molecular Thyroid Research, Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21827.ORCID 0000-0003-0958-7840
Rengyun LiuLaboratory for Cellular and Molecular Thyroid Research, Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21827.
Guangwu ZhuLaboratory for Cellular and Molecular Thyroid Research, Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21827.ORCID 0000-0003-2533-7171
Christopher B UmbrichtDepartment of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD 21278.ORCID 0000-0002-1993-0553
Mingzhao XingLaboratory for Cellular and Molecular Thyroid Research, Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21827; mxing1@jhmi.edu.ORCID 0000-0003-4797-610X
Johns Hopkins University · US

Funding

TERT Promoter Mutations in Thyroid CancerR01CA189224 · NCI · JOHNS HOPKINS UNIVERSITY · PI XING, MICHAEL MINGZHAO · 2015 to 2019
$1.8M
Molecular Events in the PI3K/AKT Pathway in Thyroid CancerR01CA215142 · NCI · JOHNS HOPKINS UNIVERSITY · PI XING, MICHAEL MINGZHAO · 2018 to 2019
$723k
NCI NIH HHS R01 CA189224NCI NIH HHS R01 CA215142
6 · The paper itself

Abstract

Combination use of BRAF V600E inhibitor dabrafenib and MEK inhibitor trametinib has become a standard treatment for human cancers harboring

Indexed as

MutationAnimalsApoptosisCell DeathCell Line, TumorColonic NeoplasmsDrug Resistance, NeoplasmFemaleHumansImidazolesMelanomaMice, NudeMitogen-Activated Protein KinasesOximesPromoter Regions, GeneticProtein Kinase InhibitorsBRAF protein, humandabrafenibImidazolesMitogen-Activated Protein KinasesOximesProtein Kinase InhibitorsProto-Oncogene Proteins B-rafPyridonesPyrimidinonesTelomeraseTERT protein, humantrametinibapoptosisBRAF inhibitorBRAF V600EMEK inhibitorTERT promoter mutation

Identifiers

PMID32561648
PMCPMC7355024
OpenAlexW3036701447

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.