Evidence map›Paper›PMID 32561581›Full record

ArticleApplied and environmental microbiology2020

Squalene-Tetrahymanol Cyclase Expression Enables Sterol-Independent Growth of Saccharomyces cerevisiae.

Sanne J Wiersma, Christiaan Mooiman, Martin Giera, Jack T Pronk

Open access · hybridAbstract read
In one paragraph

Article in Applied and environmental microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Optimization of Chemical Defined Medium forEngineering in life sciences · 2025
    Article
  3. Article
  4. Biosynthesis of lanosterol inSynthetic and systems biotechnology · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. A squalene-hopene cyclase inProceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  11. Article
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Sanne J WiersmaDepartment of Biotechnology, Delft University of Technology, Delft, The Netherlands.
Christiaan MooimanDepartment of Biotechnology, Delft University of Technology, Delft, The Netherlands.
Martin GieraCenter for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, The Netherlands.
Jack T PronkDepartment of Biotechnology, Delft University of Technology, Delft, The Netherlands j.t.pronk@tudelft.nl.ORCID 0000-0002-5617-4611
Delft University of Technology · NLLeiden University Medical Center · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biosynthesis of sterols, which are considered essential components of virtually all eukaryotic membranes, requires molecular oxygen. Anaerobic growth of the yeast

Indexed as

Gene ExpressionBiological EvolutionGene Transfer, HorizontalLyasesMicroorganisms, Genetically-ModifiedProtozoan ProteinsSaccharomyces cerevisiaeSterolsTetrahymena thermophilaLyasesProtozoan Proteinssqualene cyclaseSterolsanaerobicmembrane compositionoxygen requirementsSaccharomyces cerevisiaesterolstetrahymanol

Identifiers

PMID32561581
PMCPMC7440791
OpenAlexW3036655298

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.