ArticleBehavioural brain research2020
Contextual processing elicits sex differences in dorsal hippocampus activation following footshock and context fear retrieval.
Article in Behavioural brain research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 37 citations in OpenAlex.
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- Effect of chronic alcohol exposure and single-prolonged stress on conditioned fear behavior.Behavioural brain research · 2025Article
- Sex Differences in Neural Circuits Underlying Fear Processing.Current topics in behavioral neurosciences · 2025Review
- Sex differences in contextual fear expression are associated with altered medial prefrontal cortex activity.bioRxiv : the preprint server for biology · 2024Article
- Sex-dependent effects of acute stress in adolescence or adulthood on appetitive motivation.Psychopharmacology · 2024Article
- Climbing Fiber Activation Induced by Footshock in the Cerebellar Vermis Lobule IV/V of Freely Moving Mice.Physiological research · 2024Article
- Pharmacological diacylglycerol lipase inhibition impairs contextual fear extinction in mice.Psychopharmacology · 2024Article
- Sex differences in hippocampal β-adrenergic receptor subtypes drive retrieval, retention, and learning of cocaine-associated memories.Frontiers in behavioral neuroscience · 2024Article
- Retrieval and savings of contextual fear memories across an extended retention interval in juvenile and adult male and female rats.Behavioral neuroscience · 2023Article
- New perspectives on sex differences in learning and memory.Trends in endocrinology and metabolism: TEM · 2023Review
- Contributions of gonadal hormones in the sex-specific organization of context fear learning.PloS one · 2023Article
- Sex differences in fear responses: Neural circuits.Neuropharmacology · 2023Review
- Sex differences in contextual fear learning and generalization: a behavioral and computational analysis of hippocampal functioning.Learning & memory (Cold Spring Harbor, N.Y.) · 2022Article
- Sex differences in contextual pattern separation, neurogenesis, and functional connectivity within the limbic system.Biology of sex differences · 2022Article
- Sex and age differences in cognitive bias and neural activation in response to cognitive bias testing.Neurobiology of stress · 2022Article
- The role of hippocampus in memory reactivation: an implication for a therapeutic target against opioid use disorder.Current addiction reports · 2022Review
- Engram Size Varies with Learning and Reflects Memory Content and Precision.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Commentary: The Risky Closed Economy: A Holistic, Longitudinal Approach to Studying Fear and Anxiety in Rodents.Frontiers in behavioral neuroscience · 2021Article
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2 authors at 2 institutions in 1 country.
Funding
Abstract
Establishing a contextual representation of an environment places specific spatial-temporal processing demands on the mammalian hippocampus, a region showing sex-differences in processing capabilities. However, evidence for sex differences in these processing demands during contextual fear learning remains limited. Here, we examined the relationship among contextual processing, timing of footshock, and activation of the dorsal hippocampus and basolateral amygdalar nuclei (BLA) in male and female mice (C57Bl/6 J). We modified the initial exposure time to the conditioning context prior to administration, or not, of a single footshock. We then quantified Fos- ir neurons activated by acquisition or retrieval of contextual fear memories in the rostral half of the dorsal CA1 (proximal - distal regions), CA3, Dentate Gyrus and basolateral amygdalar nuclei corresponding to atlas levels of the Allen Reference Atlas. In experiment 1, we found that sex differences in context elicited freezing were evident at the longest context placement-to-shock interval and that context fear retrieval with increasing contextual exposure periods increased CA1 Fos-ir in males, but not females. In experiment 2, we observed that an aversive footshock in males potentiated CA1 activation, while it downregulated CA1 activation in females. We also found that an aversive footshock independent of sex moderated Dentate Gyrus activation that normally showed increased activation with greater context exposure periods. Lastly, we identified a heightened responsiveness in BLA neurons to both footshock and length of context exposure in females compared to males. Overall, our findings suggest that sex differences in contextual fear conditioning may arise from marked sex differences in the contextual processing demands of the dorsal hippocampus subfields largely modulated by aversive outcomes.
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