Evidence map›Paper›PMID 32561222›Full record

ArticleBrain, behavior, and immunity2020

Spectrum of neuropsychiatric manifestations in COVID-19.

Krishna Nalleballe, Sanjeeva Reddy Onteddu, Rohan Sharma, Vasuki Dandu, Aliza Brown, Madhu Jasti, Sisira Yadala, Karthika Veerapaneni, Suman Siddamreddy, Akshay Avula and 3 more

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In one paragraph

Article in Brain, behavior, and immunity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 132 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
132citing papers in PubMed, 14 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

132 citing papers in PubMed, 14 syntheses or guidelines pooled it.

  1. Pooled it
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  3. SARS-CoV-2 Infection and the Risk of Suicidal and Self-Harm Thoughts and Behaviour: A Systematic Review.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2022
    Pooled it
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  5. Neurological and Head/Eyes/Ears/Nose/Throat Manifestations of COVID-19: A Systematic Review and Meta-Analysis.The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques · 2022
    Pooled it
  6. Health-related quality of life issues, including symptoms, in patients with active COVID-19 or post COVID-19; a systematic literature review.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2021
    Pooled it
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  11. Stroke as a Neurological Complication of COVID-19: A Systematic Review and Meta-Analysis of Incidence, Outcomes and Predictors.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2021
    Pooled it
  12. COVID-19, de novo seizures, and epilepsy: a systematic review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021
    Pooled it
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  15. Review
  16. Article
  17. COVID-19 and Mania: A Case with a One-year Follow UP.Turk psikiyatri dergisi = Turkish journal of psychiatry · 2025
    Article
  18. Review
  19. Review
  20. Article

72 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Krishna NalleballeDepartment of Neurology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Sanjeeva Reddy OntedduDepartment of Neurology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Rohan SharmaDepartment of Neurology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Vasuki DanduDepartment of Medicine, UAMS/Baptist Health Program, North Little Rock, AR, USA.
Aliza BrownDepartment of Neurology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Madhu JastiDepartment of Neurology, University of Maryland Baltimore Washington Medical Center, Glen Burnie, MD, USA.
Sisira YadalaDepartment of Neurology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Karthika VeerapaneniDepartment of Neurology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Suman SiddamreddyDepartment of Medicine, UAMS/Baptist Health Program, North Little Rock, AR, USA.
Akshay AvulaDepartment of Medicine, Staten Island University Hospital, New York, NY, USA.
Nidhi KapoorDepartment of Neurology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Kamran MudassarDepartment of Radiology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Sukanthi KovvuruDepartment of Neurology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Corona Virus Disease 2019 (COVID-19) emerged in December 2019 from Wuhan, China. It typically presents with mild upper respiratory tract infection symptoms and may have life threatening complications, including acute respiratory distress syndrome, acute stroke, myocardial infarction, kidney failure, shock, and even death. Coronavirus infections are known to have neuroinvasive potential with consequent neuropsychiatric manifestations. We analyzed COVID-19 adult patients in the TriNetX database, which is a global health collaborative clinical research platform collecting real-time electronic medical records data from a network of health care organizations (HCOs) from January 20, 2020 to June 10th, 2020. 40,469 patients were diagnosed with COVID-19 among whom 9086 (22.5%) patients had neuropsychiatric manifestations. The most common neurologic manifestations included headache (3.7%) and sleep disorders (3.4%), Encephalopathy (2.3%), Stroke and transient ischemic attack (TIA) (1.0%) and 0.6% had seizures. Most common psychiatric manifestations included anxiety and other related disorders (4.6%), mood disorders (3.8%), while 0.2% patients had suicidal ideation. Early recognition and prompt management of neuropsychiatric manifestations in these patients have a potential to decrease overall morbidity and mortality.

Indexed as

AdolescentAdultAgedAged, 80 and overAgeusiaAnxietyBetacoronavirusBrain DiseasesCoronavirus InfectionsCOVID-19Databases, FactualFemaleHeadacheHumansIschemic Attack, TransientMale

Identifiers

PMID32561222
PMCPMC7297688

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.