ArticleJournal of affective disorders2020
Limbic white matter structural integrity at 3 months prospectively predicts negative emotionality in 9-month-old infants: a preliminary study.
Article in Journal of affective disorders, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 14 citations in OpenAlex.
- Neonatal Brain Volumes and Early Parenting Behavior as Mediators in Associations Between Prenatal Social Disadvantage and Socioemotional Problems in Toddlers.Biological psychiatry · 2026Article
- The promise of infant MRI in psychiatry: toward a framework for neural network measures in early emotional and behavioral risk identification and new intervention targets.Molecular psychiatry · 2026Review
- Associations among white matter microstructural changes and the development of emotional reactivity and regulation in infancy.Molecular psychiatry · 2025Article
- Early infant white matter tract microstructure predictors of subsequent change in emotionality and emotional regulation.Genomic psychiatry : advancing science from genes to society · 2025Article
- Association between prenatal maternal sleep quality, neonatal uncinate fasciculus white matter, and infant negative emotionality.EBioMedicine · 2024Article
- Effects of multiple anesthetic exposures on rhesus macaque brain development: a longitudinal structural MRI analysis.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- The association between cortical gyrification and sleep in adolescents and young adults.Sleep · 2024Article
- The role of sleep disturbances in associations between early life adversity and subsequent brain and language development during childhood.Frontiers in sleep · 2024Article
- Building a neurobiological framework to elucidate neural mechanisms, aid early risk detection, and develop new treatments for Bipolar Disorder.Psychiatry research · 2023Review
- The association between cortical gyrification and sleep in adolescents and young adults.bioRxiv : the preprint server for biology · 2023Article
- Neural Network Functional Interactions Mediate or Suppress White Matter-Emotional Behavior Relationships in Infants.Biological psychiatry · 2023Article
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16 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundLittle is known about how early alterations in white matter relate to clinically relevant behaviors such as emotional dysregulation. Thus, our goal was to examine how the white matter structural integrity of key limbic (i.e., uncinate fasciculus and cingulum) and commissural (i.e., forceps minor) bundles in 3-month-old infants prospectively predicts emotional regulation behaviors at 9 months.
methodsThree-month-old infants underwent multishell diffusion-weighted imaging. Following image processing, tractography was performed for each tract within each infant's native space (n=20). Measures of white matter integrity, including microstructure and morphology, were extracted from each tract. At 9 months, negative emotionality (NE) and positive emotionality (PE) were elicited using Laboratory Assessment of Temperament tasks. Elastic net regressions were performed for variable selection, which included white matter integrity variables from each of the 3 tracts, along with several covariates, including age, sex, use of public assistance, and the mother's depressive symptoms. Outcome variables were NE and PE composite scores evaluated in two separate models.
resultsNotably, following hierarchical regression using elastic net-selected variables, uncinate structural integrity was the most robust predictor of NE (ß=-0.631, p=0.005). LIMITATIONS: The sample size of our study is a limitation, however, as a preliminary study, our goal was to describe our findings to inform future, larger studies.
conclusionsGreater uncinate structural integrity predicted lower NE, suggesting that greater uncinate structural integrity at 3 months allows greater emotional regulation capacity at 9 months. To our knowledge, this is the first study to demonstrate prospective brain-to-emotional behavior relationships in infants.
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