ArticleBMC plant biology2020
Ectopic expression of miRNA172 in tomato (Solanum lycopersicum) reveals novel function in fruit development through regulation of an AP2 transcription factor.
Article in BMC plant biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 69 citations in OpenAlex.
- Ethylene networking in fruit ripening: molecular mechanisms, hormone crosstalk, climate interactions, and postharvest management.Plant cell reports · 2026Review
- MicroRNA-Mediated Hormonal Control of Fruit Morphology.Plants (Basel, Switzerland) · 2026Review
- Transcriptional control of tomato fruit development and ripening.Journal of experimental botany · 2025Review
- SlPLT6 controls ripening initiation and quality traits through modulation of histone acetylation and methylation in tomato.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- AnPlants (Basel, Switzerland) · 2025Article
- Ethylene response factor SlERF.D6 promotes ripening in part through transcription factors SlDEAR2 and SlTCP12.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Detection of Ethylene Signaling Using Bioinformatics Tools in Plants.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Integrated Transcriptome and sRNAome Analysis Reveals the Molecular Mechanisms ofInternational journal of molecular sciences · 2024Article
- Genome-wide characterization and expression profiling of E2F/DP gene family members in response to abiotic stress in tomato (Solanum lycopersicum L.).BMC plant biology · 2024Article
- T2T reference genome assembly and genome-wide association study reveal the genetic basis of Chinese bayberry fruit quality.Horticulture research · 2024Article
- Characterization of MicroRNAs and Gene Expression in ACC Oxidase RNA Interference-Based Transgenic Bananas.Plants (Basel, Switzerland) · 2023Article
- Screening of Reference miRNA of Different Early- and Late-Flowering Tree Peony Varieties.Plants (Basel, Switzerland) · 2023Article
- Current insights into posttranscriptional regulation of fleshy fruit ripening.Plant physiology · 2023Review
- Coordinating Diverse Functions of miRNA and lncRNA in Fleshy Fruit.Plants (Basel, Switzerland) · 2023Review
- Whole-transcriptome profiles of Chrysanthemum seticuspe improve genome annotation and shed new light on mRNA-miRNA-lncRNA networks in ray florets and disc florets.BMC plant biology · 2022Article
- Tomato MicroRNAs and Their Functions.International journal of molecular sciences · 2022Review
- Screening of differentially expressed microRNAs and target genes in two potato varieties under nitrogen stress.BMC plant biology · 2022Article
- The Characters of Non-Coding RNAs and Their Biological Roles in Plant Development and Abiotic Stress Response.International journal of molecular sciences · 2022Review
- Cultivar-biased regulation of HSFA7 and HSFB4a govern high-temperature tolerance in tomato.Planta · 2022Article
- APETALA2/ethylene responsive factor in fruit ripening: Roles, interactions and expression regulation.Frontiers in plant science · 2022Review
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Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
Abstract
backgroundMicroRNAs (miRNAs) are short non-coding RNAs that can influence gene expression via diverse mechanisms. Tomato is a fruit widely consumed for its flavor, culinary attributes, and high nutritional quality. Tomato fruit are climacteric and fleshy, and their ripening is regulated by endogenous and exogenous signals operating through a coordinated genetic network. Much research has been conducted on mechanisms of tomato fruit ripening, but the roles of miRNA-regulated repression/expression of specific regulatory genes are not well documented.
resultsIn this study, we demonstrate that miR172 specifically targets four SlAP2 transcription factor genes in tomato. Among them, SlAP2a was repressed by the overexpression of SlmiR172, manifesting in altered flower morphology, development and accelerated ripening. miR172 over-expression lines specifically repressed SlAP2a, enhancing ethylene biosynthesis, fruit color and additional ripening characteristics. Most previously described ripening-regulatory genes, including RIN-MADS, NR, TAGL1 and LeHB-1 were not influenced by miR172 while CNR showed altered expression.
conclusionsTomato fruit ripening is directly influenced by miR172 targeting of the APETALA2 transcription factor, SlAP2a, with minimal influence over additional known ripening-regulatory genes. miR172a-guided SlAP2a expression provides insight into another layer of genetic control of ripening and a target for modifying the quality and nutritional value of tomato and possibly other fleshy fruit crops.
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