Evidence map›Paper›PMID 32560574›Full record

ReviewInternational journal of molecular sciences2020

Targeting

Iris Z Uras, Herwig P Moll, Emilio Casanova

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
82citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

82 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
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  14. ATR expression as a prognostic biomarker inJournal of thoracic disease · 2025
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22 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Iris Z UrasDepartment of Pharmacology, Center of Physiology and Pharmacology & Comprehensive Cancer Center (CCC), Medical University of Vienna, 1090 Vienna, Austria.ORCID 0000-0002-2434-2756
Herwig P MollDepartment of Physiology, Center of Physiology and Pharmacology & Comprehensive Cancer Center (CCC), Medical University of Vienna, 1090 Vienna, Austria.ORCID 0000-0001-6438-9068
Emilio CasanovaDepartment of Physiology, Center of Physiology and Pharmacology & Comprehensive Cancer Center (CCC), Medical University of Vienna, 1090 Vienna, Austria.ORCID 0000-0001-7992-5361

Funding

Austrian Science Fund P 25599Austrian Science Fund P 32900Austrian Science Fund FWF P 25599Austrian Science Fund FWF P 32900DOC 59-B33the Comprehensive Cancer Center research grant N/Athe Fellinger Krebsforschungsverein N/Athe Fund of City of Vienna for innovative, interdisciplinary cancer research N/A
6 · The paper itself

Abstract

Lung cancer is the most frequent cancer with an aggressive clinical course and high mortality rates. Most cases are diagnosed at advanced stages when treatment options are limited and the efficacy of chemotherapy is poor. The disease has a complex and heterogeneous background with non-small-cell lung cancer (NSCLC) accounting for 85% of patients and lung adenocarcinoma being the most common histological subtype. Almost 30% of adenocarcinomas of the lung are driven by an activating

Indexed as

Biomarkers, TumorMutationAMP-Activated Protein Kinase KinasesAnimalsAntineoplastic AgentsCarcinoma, Non-Small-Cell LungErbB ReceptorsHumansLung NeoplasmsMolecular Targeted TherapyProtein Serine-Threonine KinasesProto-Oncogene Proteins p21(ras)Tumor Suppressor Protein p53AMP-Activated Protein Kinase KinasesAntineoplastic AgentsBiomarkers, TumorEGFR protein, humanErbB ReceptorsKRAS protein, humanProtein Serine-Threonine KinasesProto-Oncogene Proteins p21(ras)STK11 protein, humanTP53 protein, humanTumor Suppressor Protein p53degradersEGFRimmunotherapyKRASlung adenocarcinomametabolic rewiringNSCLCp53STK11targeted therapy

Identifiers

PMID32560574
PMCPMC7352653

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.