Evidence map›Paper›PMID 32560390›Full record

ArticlePharmaceutics2020

PH-Responsive, Cell-Penetrating, Core/Shell Magnetite/Silver Nanoparticles for the Delivery of Plasmids: Preparation, Characterization, and Preliminary

Carlos M Ramírez-Acosta, Javier Cifuentes, Maria Claudia Castellanos, Rodolfo José Moreno, Carolina Muñoz-Camargo, Juan C Cruz, Luis H Reyes

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 46 citations in OpenAlex.

  1. Review
  2. Article
  3. Nanocarrier-mediated CRISPR-Cas delivery: a novel approach against antibiotic-resistant superbugs.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2026
    Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Assessment of CRISPRa-mediatedFrontiers in bioengineering and biotechnology · 2024
    Article
  9. Article
  10. Article
  11. The importance of basic and translational research in caring for children with malignant solid tumors in Latin America.Revista panamericana de salud publica = Pan American journal of public health · 2024
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Carlos M Ramírez-AcostaGrupo de Diseño de Productos y Procesos (GDPP), Department of Chemical and Food Engineering, Universidad de los Andes, Bogotá 111711, Colombia.ORCID 0000-0003-3797-3933
Javier CifuentesDepartment of Biomedical Engineering, Universidad de los Andes, Bogotá 111711, Colombia.
Maria Claudia CastellanosDepartment of Biomedical Engineering, Universidad de los Andes, Bogotá 111711, Colombia.
Rodolfo José MorenoGrupo de Diseño de Productos y Procesos (GDPP), Department of Chemical and Food Engineering, Universidad de los Andes, Bogotá 111711, Colombia.
Carolina Muñoz-CamargoDepartment of Biomedical Engineering, Universidad de los Andes, Bogotá 111711, Colombia.
Juan C CruzDepartment of Biomedical Engineering, Universidad de los Andes, Bogotá 111711, Colombia.ORCID 0000-0002-7790-7546
Luis H ReyesGrupo de Diseño de Productos y Procesos (GDPP), Department of Chemical and Food Engineering, Universidad de los Andes, Bogotá 111711, Colombia.ORCID 0000-0001-7251-5298
Universidad de Los Andes · CO

Funding

Minciencias 120380763212
6 · The paper itself

Abstract

Over the past decade, gene therapies have attracted much attention for the development of treatments for various conditions, including cancer, neurodegenerative diseases, protein deficiencies, and autoimmune disorders. Despite the benefits of this approach, several challenges are yet to be solved to reach clinical implementation. Some of these challenges include low transfection rates, limited stability under physiological conditions, and low specificity towards the target cells. An avenue to overcome such issues is to deliver the therapies with the aid of potent cell-penetrating vectors. Non-viral vectors, such as nanostructured materials, have been successfully tested in drug and gene delivery. Here, we propose the development and

Indexed as

core-shell nanoparticlesgene deliverymagnetitepH-responsive polymer

Identifiers

PMID32560390
PMCPMC7356180
OpenAlexW3035960414

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.