Do Genes Associated with Dyslexia of Chinese Characters Evolve Neutrally?

Kumiko V Nishiyama, Yoko Satta, Jun Gojobori

Open access · goldAbstract read

In one paragraph

Article in Genes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

0.5field-weighted citation impact, top 31% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Kumiko V NishiyamaDepartment of Evolutionary Studies of Biosystems, SOKENDAI The Graduate University for Advanced Studies, Kanagawa 240-0193, Japan.

Yoko SattaDepartment of Evolutionary Studies of Biosystems, SOKENDAI The Graduate University for Advanced Studies, Kanagawa 240-0193, Japan.ORCID 0000-0002-5305-493X

Jun GojoboriDepartment of Evolutionary Studies of Biosystems, SOKENDAI The Graduate University for Advanced Studies, Kanagawa 240-0193, Japan.ORCID 0000-0002-7699-7746

The Graduate University for Advanced Studies, SOKENDAI · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dyslexia, or reading disability, is found to have a genetic basis, and several related genes have been reported. We investigated whether natural selection has acted on single nucleotide polymorphisms (SNPs) that were reported to be associated with risk/non-risk for the reading disability of Chinese characters. We applied recently developed 2D SFS-based statistics to SNP data of East Asian populations to examine whether there is any sign of selective sweep. While neutrality was not rejected for most SNPs, significant signs of selection were detected for two linkage disequilibrium (LD) regions containing the reported SNPs of

Indexed as

AllelesAsian PeopleBiological EvolutionDyslexiaFemaleHumansLinkage DisequilibriumMaleMicrotubule-Associated ProteinsPolymorphism, Single NucleotideReadingSelection, GeneticTransferases (Other Substituted Phosphate Groups)DCDC2 protein, humanGNPTAB protein, humanMicrotubule-Associated ProteinsTransferases (Other Substituted Phosphate Groups)2D SFS-based statisticsdyslexiaEast Asian populationsgenetic hitchhikingnSLpopulation geneticsselective sweep

Identifiers

PMID32560373

DOI10.3390/genes11060658

PMCPMC7349701

OpenAlexW3036012336

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.