Evidence map›Paper›PMID 32560276›Full record

Observational studyInternational journal of molecular sciences2020

Evaluation of Prognostic Factors of Severity in Acute Biliary Pancreatitis.

Pedro Silva-Vaz, Ana Margarida Abrantes, Sara Morgado-Nunes, Miguel Castelo-Branco, António Gouveia, Maria Filomena Botelho, José Guilherme Tralhão

Open access · goldAbstract readComparative StudyObservational Study
In one paragraph

Observational study in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 2 pooled it
7.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 61 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Pedro Silva-VazHealth Sciences Research Centre, University of Beira Interior (CICS-UBI), 6200-506 Covilhã, Portugal.ORCID 0000-0002-2979-1024
Ana Margarida AbrantesBiophysics Institute, Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal.
Sara Morgado-NunesClinical Academic Centre of Beiras, CACB, 6200-506 Covilhã, Portugal.ORCID 0000-0003-2944-306X
Miguel Castelo-BrancoHealth Sciences Research Centre, University of Beira Interior (CICS-UBI), 6200-506 Covilhã, Portugal.
António GouveiaGeneral Surgery Department, Hospital Amato Lusitano, Unidade Local de Saúde de Castelo Branco, 6000-085 Castelo Branco, Portugal.
Maria Filomena BotelhoBiophysics Institute, Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal.ORCID 0000-0001-7202-1650
José Guilherme TralhãoBiophysics Institute, Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal.
University of Beira Interior · PTUniversity of Coimbra · PTHospitais da Universidade de Coimbra · PTPolytechnic Institute of Castelo Branco · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute pancreatitis (AP) is an inflammatory disorder of the pancreas that, when classified as severe, is associated with high morbidity and mortality. Promptly identifying the severity of AP is of extreme importance for improving clinical outcomes. The aim of this study was to compare the prognostic value of serological biomarkers, ratios, and multifactorial scores in patients with acute biliary pancreatitis and to identify the best predictors. In this observational and prospective study, the biomarkers, ratios and multifactorial scores were evaluated on admission and at 48 h of the symptom onset. On admission, regarding the AP severity, the white blood count (WBC) and neutrophil-lymphocyte ratio (NLR), and regarding the mortality, the WBC and the modified Marshall score (MMS) showed the best predictive values. At 48 h, regarding the AP severity, the hepcidin, NLR, systemic inflammatory response index (SIRI) and MMS and regarding the mortality, the NLR, hepcidin and the bedside index for severity in AP (BISAP) score, showed the best predictive values. The present study enabled the identification, for the first time, of SIRI as a new prognostic tool for AP severity, and validated hepcidin and the NLR as better prognostic markers than C-reactive protein (CRP) at 48 h of symptom onset.

Indexed as

AdultAgedAged, 80 and overBiomarkersFemaleHepcidinsHumansLeukocyte CountLymphocyte CountMaleMiddle AgedPancreatitisPredictive Value of TestsPrognosisProspective StudiesSeverity of Illness IndexBiomarkersHepcidinsacute biliary pancreatitishepcidininflammationprognosticseveritysystemic inflammatory response index

Identifiers

PMID32560276
PMCPMC7352282
OpenAlexW3034349328

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.