Evidence map›Paper›PMID 32560166›Full record

ArticleNutrients2020

SNP rs6564851 in the BCO1 Gene Is Associated with Varying Provitamin a Plasma Concentrations but Not with Retinol Concentrations among Adolescents from Rural Ghana.

Sophie Graßmann, Olga Pivovarova-Ramich, Andrea Henze, Jens Raila, Yaw Ampem Amoako, Richard King Nyamekye, George Bedu-Addo, Frank P Mockenhaupt, Matthias B Schulze, Ina Danquah

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.2field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 2 countries.

Sophie GraßmannDepartment Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), 14558 Nuthetal, Germany.
Olga Pivovarova-RamichResearch Group Molecular Nutritional Medicine, Department of Molecular Toxicology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), 14558 Nuthetal, Germany.ORCID 0000-0002-3583-8546
Andrea HenzeJunior Research Group ProAID, Institute of Nutritional Science, Potsdam University, 14558 Nuthetal, Germany.
Jens RailaPhysiology and Pathophysiology of Nutrition, Institute of Nutrition Science, Potsdam University, 14558 Nuthetal, Germany.
Yaw Ampem AmoakoKomfo Anokye Teaching Hospital, Kwame Nkrumah University of Science and Technology (KNUST), P.O. Box 1934 Kumasi, Ghana.
Richard King NyamekyeAgogo Presbyterian Hospital, P.O. Box 27 Agogo, Ghana.
George Bedu-AddoKomfo Anokye Teaching Hospital, Kwame Nkrumah University of Science and Technology (KNUST), P.O. Box 1934 Kumasi, Ghana.
Frank P MockenhauptInstitute of Tropical Medicine and International Health, Charité-Universitaetsmedizin Berlin, 13353 Berlin, Germany.
Matthias B SchulzeDepartment Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), 14558 Nuthetal, Germany.ORCID 0000-0002-0830-5277
Ina DanquahDepartment Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), 14558 Nuthetal, Germany.
German Institute of Human Nutrition · DEKomfo Anokye Teaching Hospital · GHCharité - Universitätsmedizin Berlin · DEDeutsches Diabetes-Zentrum e.V. · DEHeidelberg University · DEPresbyterian University, Ghana · GHUniversity of Potsdam · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In sub-Saharan Africa, vitamin A deficiency constitutes a severe health problem despite various supplementation and food fortification programs. Given that the intake of preformed vitamin A from animal products remains low in these countries, an efficient metabolization of plant-based provitamin A carotenoids is essential. Previously, adolescents in rural Ghana have shown high total plasma carotenoid concentrations, while 36% had a vitamin A deficiency (defined as plasma retinol < 0.7 µmol/L). Hence, the aim of this cross-sectional study was to identify the relationships between variants in the β-carotene 15,15'-oxygenase (BCO1) gene and plasma carotenoid concentrations among 189 15-year-old girls and boys in rural Ghana.

Indexed as

AdolescentAllelesbeta-Carotene 15,15'-MonooxygenaseCarotenoidsCross-Sectional StudiesDietFemaleGenotypeGhanaHumansMalePolymorphism, Single NucleotideProvitaminsRural PopulationSocioeconomic FactorsVitamin ABCO1 protein, humanbeta-Carotene 15,15'-MonooxygenaseCarotenoidsProvitaminsVitamin ABCO1carotenoidsGhanasingle nucleotide polymorphismvitamin A deficiency

Identifiers

PMID32560166
PMCPMC7353293
OpenAlexW3034909427

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.