Evidence map›Paper›PMID 32560153›Full record

ArticleBiosensors2020

The Effect of Optically Induced Dielectrophoresis (ODEP)-Based Cell Manipulation in a Microfluidic System on the Properties of Biological Cells.

Po-Yu Chu, Chia-Hsun Hsieh, Chien-Ru Lin, Min-Hsien Wu

Open access · goldAbstract read
In one paragraph

Article in Biosensors, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Dielectrophoretic separation of blood cells.Biomedical microdevices · 2022
    Review
  9. Article
  10. Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Po-Yu ChuPh.D. Program in Biomedical Engineering, Chang Gung University, Taoyuan City 33302, Taiwan.
Chia-Hsun HsiehDivision of Haematology/Oncology, Department of Internal Medicine, New Taipei Municipal Hospital, New Taipei City 23600, Taiwan.
Chien-Ru LinGraduate Institute of Biomedical Engineering, Chang Gung University, Taoyuan City 33302, Taiwan.
Min-Hsien WuDivision of Haematology/Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital at Linkou, Taoyuan City 33302, Taiwan.
Chang Gung University · TWMing Chi University of Technology · TW

Funding

Chang Gung Memorial Hospital CMRPD2G0061-62, CMRPD2H0121-23, and CMRPD2J0031-32Ministry of Science and Technology, Taiwan MOST 107-2221-E-182-033-MY3
6 · The paper itself

Abstract

Cell manipulation using optically induced dielectrophoresis (ODEP) in microfluidic systems has attracted the interest of scientists due to its simplicity. Although this technique has been successfully demonstrated for various applications, one fundamental issue has to be addressed-Whether, the ODEP field affects the native properties of cells. To address this issue, we explored the effect of ODEP electrical conditions on cellular properties. Within the experimental conditions tested, the ODEP-based cell manipulation with the largest velocity occurred at 10 Vpp and 1 MHz, for the two cancer cell types explored. Under this operating condition, however, the cell viability of cancer cells was significantly affected (e.g., 70.5 ± 10.0% and 50.6 ± 9.2% reduction for the PC-3 and SK-BR-3 cancer cells, respectively). Conversely, the exposure of cancer cells to the ODEP electrical conditions of 7-10 Vpp and 3-5 MHz did not significantly alter the cell viability, cell metabolic activity, and the

Indexed as

Biosensing TechniquesMicrofluidic Analytical TechniquesOptical ImagingCell Line, TumorHumansPC-3 Cellscell manipulationcell physiologycell propertymicrofluidic systemsoptically induced dielectrophoresis

Identifiers

PMID32560153
PMCPMC7345979
OpenAlexW3035520560

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.