ReviewInternational journal of environmental research and public health2020
Evidences from Clinical Trials in Down Syndrome: Diet, Exercise and Body Composition.
Review in International journal of environmental research and public health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Socio-Ecological Factors of Physical Activity in Children and Adolescents With Down Syndrome: A Mixed-Methods Systematic Review.Journal of intellectual disability research : JIDR · 2026Pooled it
- Weight-loss interventions for adolescents with Down syndrome: a systematic review.Obesity (Silver Spring, Md.) · 2025Pooled it
- Physical activity based interventions for reducing body mass index in children aged 6-12 years: a systematic review.Frontiers in pediatrics · 2025Pooled it
- Understanding Obesity in Individuals with Down Syndrome: Caregiver Perceptions, Awareness, and Motivation.Nutrients · 2026Article
- Nutrient Intake and Physical Activity of School-Aged Children with Trisomy 21 Living in Manitoba, Canada.Nutrients · 2026Article
- Telomere Biology, Erosion, and Age-Related Conditions: Insights from Down Syndrome and Other Telomere-Associated Disorders.Molecular neurobiology · 2025Review
- Perioperative Complications in Children with Down Syndrome: A Single Center Retrospective Analysis-Original Clinical Research Report.Journal of clinical medicine · 2025Article
- A descriptive analysis of sarcopenia markers in young adults with down syndrome.Experimental gerontology · 2025Article
- Impact of Resistance Training on Body Composition and Physical Function in Individuals with Down Syndrome: A Meta-Analysis.Diagnostics (Basel, Switzerland) · 2024Review
- Article
- General Dietary Recommendations for People with Down Syndrome.Nutrients · 2024Review
- Article
- Body composition parameters and sarcopenia in adults with Down syndrome: a case-control study.Aging clinical and experimental research · 2024Article
- Diet and physical activity modification: impact on adaptive behavior and biochemical measures of children with Down syndrome.International journal of developmental disabilities · 2024Article
- Effects of exercise, physical activity, and sports on physical fitness in adults with Down syndrome: A systematic review.AIMS public health · 2024Review
- Article
- Energy expenditure and weight-related behaviors in youth with Down syndrome: a protocol.Frontiers in pediatrics · 2023Article
- Quantitative magnetic resonance characterization of the effect of physical training on skeletal muscle of the Ts65Dn mice, a model of Down syndrome.Quantitative imaging in medicine and surgery · 2022Article
- Examining older adults with neuroatypical conditions for MCI/dementia: Barriers and recommendations of the Neuroatypical Conditions Expert Consultative Panel.Alzheimer's & dementia (Amsterdam, Netherlands) · 2022Review
- Sleep Disorders in Adults with Down Syndrome.Journal of clinical medicine · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Down syndrome (DS) is related to diseases like congenital heart disease, obstructive sleep apnea, obesity and overweight. Studies focused on DS associated with obesity and overweight are still scarce. The main objective of this work was to analyze the relationship between dietary intervention, physical exercise and body composition, in DS with overweight and obesity. This review is based on the PRISMA guidelines (Preferred Reporting Items for Systematic reviews and Meta-Analyses). Selection criteria for this analysis were: publications between January 1997 and December 2019; DS individuals with overweight and obesity; clinical trials using dietary intervention and physical exercise paying attention to changes in body composition. Selected clinical trials were focused on an exclusive intervention based on physical exercise. The anthropometric measures analyzed were body fat, BMI, waist circumference, body weight and fat free mass. The main conclusion is that prescribing structured physical exercise intervention may be related to a greater variation in body composition. Despite limited number of clinical trials analyzed, it can be assumed that the reported studies have not achieved optimal results and that the design of future clinical trials should be improved. Some guidelines are proposed to contribute to the improvement of knowledge in this field.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.